ACTIVE_NOT_RECRUITING

A Study Investigating the Efficacy and Safety of Intravitreal (IVT) Injections of Vonaprument (Formerly ANX007) in Participants With Geographic Atrophy (GA)

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Conditions

Geographic Atrophy

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The primary purpose of the study is to determine if IVT injections of vonaprument every month reduce vision loss in participants with GA secondary to age-related macular degeneration (AMD).

Official Title

A Phase 3, Multicenter, Randomized, Parallel-Group, Double-Masked, 2-Arm, Sham Controlled Study of the Efficacy, Safety, and Tolerability of ANX007 Administered by Intravitreal Injection in Patients With Geographic Atrophy (GA) Secondary to Age Related Macular Degeneration (AMD)

Quick Facts

Study Start:2024-07-30
Study Completion:2027-10-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:ACTIVE_NOT_RECRUITING

Study ID

NCT06510816

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:50 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Diagnosis of GA of the macula secondary to AMD as determined by the Investigator and confirmed by the independent Central Reading Center.
  1. * Geographic atrophy due to other causes than AMD such as Stargardt disease, cone-rod dystrophy, pathologic myopia, or toxic maculopathies (for example, plaquenil maculopathy) in either eye.

Contacts and Locations

Principal Investigator

Clinical Trials
STUDY_DIRECTOR
Annexon, Inc.

Study Locations (Sites)

Retina Macula Institute of Arizona
Scottsdale, Arizona, 85255
United States
Retina-Vitreous Associates Medical Group
Beverly Hills, California, 90211
United States
RCOC Clinical Research Institute Inc
Fullerton, California, 92835
United States
Global Research Management
Glendale, California, 91204
United States
Retina Consultants Medical Group
Modesto, California, 95356
United States
Northern California Retina Vitreous Associates Medical Group, Inc.
Mountain View, California, 94040
United States
Retinal Consultants Medical Group
Sacramento, California, 95825
United States
Macula Retina Vitreous Research Institute
Torrance, California, 90503
United States
Bay Area Retina Associates
Walnut Creek, California, 94598
United States
Retina Consultants of Southern Colorado PC
Colorado Springs, Colorado, 80909
United States
RSC Research, LLC
Denver, Colorado, 80222
United States
Rand Eye Institute
Deerfield Beach, Florida, 33064
United States
National Ophthalmic Research Institute
Fort Myers, Florida, 33912
United States
Florida Retina Institute
Orlando, Florida, 32806
United States
Fort Lauderdale Eye Institute
Plantation, Florida, 33324
United States
Retina Group of Florida
Sarasota, Florida, 34233
United States
Retina Vitreous Associates of Florida
St. Petersburg, Florida, 33711
United States
East Florida Eye Institute
Stuart, Florida, 34994
United States
Georgia Retina PC
Marietta, Georgia, 30060
United States
Retina Consultants of Hawaii
‘Aiea, Hawaii, 96701
United States
Retina Associates - Elmhurst Location
Elmhurst, Illinois, 60126
United States
University Retina
Oak Forest, Illinois, 60452
United States
Springfield Clinic LLP
Springfield, Illinois, 62703
United States
Wolfe Eye Clinic
West Des Moines, Iowa, 50266
United States
Maine Eye Center
Portland, Maine, 04101
United States
Retina Group of Washington
Chevy Chase, Maryland, 20815
United States
Cumberland Valley Retina Consultants
Hagerstown, Maryland, 21740
United States
Mid Atlantic Retina Specialists
Hagerstown, Maryland, 21740
United States
Ophthalmic Consultants of Boston
Boston, Massachusetts, 02114
United States
Retina Research Institute at New England Retina Consultants
Springfield, Massachusetts, 01107
United States
Retina Consultants of Minnesota
Saint Louis Park, Minnesota, 55416
United States
Sierra Eye Associates
Reno, Nevada, 89502
United States
Envision Ocular, LLC
Bloomfield, New Jersey, 07003
United States
Mid Atlantic Retina
Cherry Hill, New Jersey, 08034
United States
Vision Research Center Eye Associates of New Mexico
Albuquerque, New Mexico, 87109
United States
Long Island Vitreoretinal Consultants
Hauppauge, New York, 11788
United States
Asheville Eye Associates - Retina Division
Asheville, North Carolina, 28803
United States
North Carolina Retina Associates
Cary, North Carolina, 27511
United States
North Carolina Retina Associates
Wake Forest, North Carolina, 27587
United States
Piedmont Retina Specialists - Winston Salem Office
Winston-Salem, North Carolina, 27103
United States
University Hospitals Cleveland Medical Center
Cleveland, Ohio, 44106
United States
Retina Vitreous Center
Edmond, Oklahoma, 73013
United States
Tulsa Retina Consultants
Tulsa, Oklahoma, 74114
United States
Verum Research, LLC
Eugene, Oregon, 97401
United States
Eyehealth Northwest Portland
Portland, Oregon, 97209
United States
Cascade Medical Research Institute
Springfield, Oregon, 97477
United States
Erie Retina Research, LLC
Erie, Pennsylvania, 16507
United States
Eye Care Specialists
Kingston, Pennsylvania, 18704
United States
Palmetto Retina Center
Aiken, South Carolina, 29801
United States
ReƟna Consultants of Charleston
Beaufort, South Carolina, 29901
United States
Charleston Neuroscience Center
Charleston, South Carolina, 29414
United States
Southeastern Retina
Chattanooga, Tennessee, 37604
United States
Retina Research Institute of Texas
Abilene, Texas, 79606
United States
Southwest Retina Specialists
Amarillo, Texas, 79106
United States
Texas Retina Associates- Arlington
Arlington, Texas, 76012
United States
Austin Research Center for Retina
Austin, Texas, 78705
United States
Austin Retina Associates
Austin, Texas, 78705
United States
Austin Clinical Research, LLC
Austin, Texas, 78750
United States
Retina Consultants of Texas
Bellaire, Texas, 77401
United States
Retina Foundation of the Southwest
Dallas, Texas, 75231
United States
Texas Retina Associates - Plano
Dallas, Texas, 75231
United States
Texas Retina Associates
Fort Worth, Texas, 76104
United States
Retina Consultants of Texas
Katy, Texas, 77494
United States
Tennessee Retina PC
Nashville, Texas, 37203
United States
Retina Consultants of Texas San Antonio
San Antonio, Texas, 78240
United States
Retina Consultants of Texas
The Woodlands, Texas, 77384
United States
Strategic Clinical Research Group, LLC
Willow Park, Texas, 76087
United States
Rocky Mountain Retina Consultants
Salt Lake City, Utah, 84107
United States
Piedmont Eye Center
Lynchburg, Virginia, 24502
United States
Eye Clinic of Wisconsin
Wausau, Wisconsin, 54403
United States

Collaborators and Investigators

Sponsor: Annexon, Inc.

  • Clinical Trials, STUDY_DIRECTOR, Annexon, Inc.

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-07-30
Study Completion Date2027-10-31

Study Record Updates

Study Start Date2024-07-30
Study Completion Date2027-10-31

Terms related to this study

Additional Relevant MeSH Terms

  • Geographic Atrophy