Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
Eligibility Criteria
- * Age 18-70 years
- * Body mass index (BMI) \>19 kg/m2 and body weight\< 250kg
- * Participants must have experienced a clinically significant weight regain, defined as over 10% of their maximum weight lost, within 1 to 5 years following their bariatric surgery. They will be asked to self-report their weight loss history. Participants must also provide the operative report from their bariatric surgery for reference.
- * In good general health with no conditions that could influence the outcome of the trial, and in the judgment of the investigator is a good candidate for the study based on review of available medical history, physical examination and clinical laboratory evaluations
- * Willing to adhere to the protocol requirements for the duration of the study
- * Type 1 diabetes mellitus
- * Peripheral neuropathy with insensate feet
- * Recent blood donation within the last 2 months
- * Use of beta-blockers
- * Current pregnancy or breastfeeding
- * Active Heart or lung disease
- * Severe hypertension (systolic \>160 mmHg or diastolic \>90 mmHg)
- * Inability to exercise for any reason
- * Any known contraindication to exercise testing based on current ACSM guidelines
- * MRI contraindications, such as presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments, or foreign objects in the eyes, skin, or body
- * Known presence of a structural brain lesion (e.g. tumor, cortical infarct)
- * Presence of another neurologic disorder, which could impact findings (e.g. multiple sclerosis)
- * History of cardiovascular disease, stroke, congestive heart failure
- * Active hematological, renal, pulmonary or hepatic disorders
- * Active treatment for cancer
- * A history of active alcohol or substance abuse
- * Any significant systemic illness or unstable medical condition which could lead to difficulty complying with the study protocol
- * History of claustrophobia and inability to tolerate an MRI
- * Body weight \>250kgr and largest body diameter of 70cm as there is a certain weight and diameter limit of the MRI scanner
- * Unwilling or unable to return for study visits, undergo neuropsychological testing and MRI imaging
- * Left-handedness
Ages Eligible for Study
18 Years to 70 Years
Sexes Eligible for Study
ALL
Accepts Healthy Volunteers
Yes