RECRUITING

Exercise, Brain Activity, and Weight Maintenance

Conditions

Obesity Weight Gain Bariatric Surgery Candidate Appetitive Behavior

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study aims to explore how HIIT influences brain function, neural and molecular pathways related to weight control, setting the stage for future obesity intervention research.

Official Title

Effects of Exercise Training on Brain Activity and Its Relation to Weight Maintenance and Appetite Regulation

Quick Facts

Study Start:2025-09-15

Study Completion:2027-07-01

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT06511310

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 70 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Age 18-70 years * Body mass index (BMI) \>19 kg/m2 and body weight\< 250kg * Participants must have experienced a clinically significant weight regain, defined as over 10% of their maximum weight lost, within 1 to 5 years following their bariatric surgery. They will be asked to self-report their weight loss history. Participants must also provide the operative report from their bariatric surgery for reference. * In good general health with no conditions that could influence the outcome of the trial, and in the judgment of the investigator is a good candidate for the study based on review of available medical history, physical examination and clinical laboratory evaluations * Willing to adhere to the protocol requirements for the duration of the study	* Type 1 diabetes mellitus * Peripheral neuropathy with insensate feet * Recent blood donation within the last 2 months * Use of beta-blockers * Current pregnancy or breastfeeding * Active Heart or lung disease * Severe hypertension (systolic \>160 mmHg or diastolic \>90 mmHg) * Inability to exercise for any reason * Any known contraindication to exercise testing based on current ACSM guidelines * MRI contraindications, such as presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments, or foreign objects in the eyes, skin, or body * Known presence of a structural brain lesion (e.g. tumor, cortical infarct) * Presence of another neurologic disorder, which could impact findings (e.g. multiple sclerosis) * History of cardiovascular disease, stroke, congestive heart failure * Active hematological, renal, pulmonary or hepatic disorders * Active treatment for cancer * A history of active alcohol or substance abuse * Any significant systemic illness or unstable medical condition which could lead to difficulty complying with the study protocol * History of claustrophobia and inability to tolerate an MRI * Body weight \>250kgr and largest body diameter of 70cm as there is a certain weight and diameter limit of the MRI scanner * Unwilling or unable to return for study visits, undergo neuropsychological testing and MRI imaging * Left-handedness

Inclusion Criteria

Exclusion Criteria

* Age 18-70 years
* Body mass index (BMI) \>19 kg/m2 and body weight\< 250kg
* Participants must have experienced a clinically significant weight regain, defined as over 10% of their maximum weight lost, within 1 to 5 years following their bariatric surgery. They will be asked to self-report their weight loss history. Participants must also provide the operative report from their bariatric surgery for reference.
* In good general health with no conditions that could influence the outcome of the trial, and in the judgment of the investigator is a good candidate for the study based on review of available medical history, physical examination and clinical laboratory evaluations
* Willing to adhere to the protocol requirements for the duration of the study

* Type 1 diabetes mellitus
* Peripheral neuropathy with insensate feet
* Recent blood donation within the last 2 months
* Use of beta-blockers
* Current pregnancy or breastfeeding
* Active Heart or lung disease
* Severe hypertension (systolic \>160 mmHg or diastolic \>90 mmHg)
* Inability to exercise for any reason
* Any known contraindication to exercise testing based on current ACSM guidelines
* MRI contraindications, such as presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments, or foreign objects in the eyes, skin, or body
* Known presence of a structural brain lesion (e.g. tumor, cortical infarct)
* Presence of another neurologic disorder, which could impact findings (e.g. multiple sclerosis)
* History of cardiovascular disease, stroke, congestive heart failure
* Active hematological, renal, pulmonary or hepatic disorders
* Active treatment for cancer
* A history of active alcohol or substance abuse
* Any significant systemic illness or unstable medical condition which could lead to difficulty complying with the study protocol
* History of claustrophobia and inability to tolerate an MRI
* Body weight \>250kgr and largest body diameter of 70cm as there is a certain weight and diameter limit of the MRI scanner
* Unwilling or unable to return for study visits, undergo neuropsychological testing and MRI imaging
* Left-handedness

Contacts and Locations

Study Contact

Maria Vamvini, MD

CONTACT

617-309-2400

Maria.Vamvini@joslin.harvard.edu

Laura Simpson, MS

CONTACT

617-735-3924

laura.simpson@joslin.harvard.edu

Principal Investigator

Maria Vamvini, MD

PRINCIPAL_INVESTIGATOR

Joslin Diabetes Center

Study Locations (Sites)

Joslin Diabetes Center

Boston, Massachusetts, 02215

United States

Collaborators and Investigators

Sponsor: Joslin Diabetes Center

Maria Vamvini, MD, PRINCIPAL_INVESTIGATOR, Joslin Diabetes Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-09-15

Study Completion Date2027-07-01

Study Record Updates

Study Start Date2025-09-15

Study Completion Date2027-07-01

Terms related to this study

Additional Relevant MeSH Terms

Obesity
Weight Gain
Bariatric Surgery Candidate
Appetitive Behavior