A Novel Imaging Modality to Evaluate Radiation-Induced Uterine Injury

Description

The goal of this pilot study is to assess the ability of a new imaging modality, shear-wave-elastography (SWE) and magnetic resonance imaging (MRI) to identify radiation-induced uterine injury (RIUI). The investigator will recruit female patients treated for colorectal or anal cancer at 15 to 39 years with ≥ 50 Gy pelvic radiation (PRT) at least 12 months prior to study initiation.

Conditions

Uterine Injury

Study Overview

Study Details

Study overview

The goal of this pilot study is to assess the ability of a new imaging modality, shear-wave-elastography (SWE) and magnetic resonance imaging (MRI) to identify radiation-induced uterine injury (RIUI). The investigator will recruit female patients treated for colorectal or anal cancer at 15 to 39 years with ≥ 50 Gy pelvic radiation (PRT) at least 12 months prior to study initiation.

A Novel Imaging Modality to Evaluate Radiation-Induced Uterine Injury

A Novel Imaging Modality to Evaluate Radiation-Induced Uterine Injury

Condition
Uterine Injury
Intervention / Treatment

-

Contacts and Locations

Aurora

University of Colorado, Aurora, Colorado, United States, 80045

Aurora

University of Colorado, Aurora, Colorado, United States, 80045

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Female
  • 2. 15 ≤ age of treatment \< 40 years
  • 3. Treated with PRT at UCH
  • 4. Received ≥ 50 Gy PRT
  • 1. Patients who underwent hysterectomy for treatment of a primary gynecologic malignancy
  • 2. Patients that are currently pregnant

Ages Eligible for Study

15 Years to 40 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Colorado, Denver,

Leslie Appiah, MD, PRINCIPAL_INVESTIGATOR, University of Colorado, Denver

Study Record Dates

2025-03