Fiber and Calcium Absorption in Older Men

Description

Osteoporotic fractures are a major but underrecognized problem in men. There is growing evidence that low dietary fiber intake is a modifiable risk factor for age-related bone loss in men. Preclinical and human studies in adolescents and postmenopausal women suggest that dietary fiber intake influences bone metabolism by modulating the gut microbiome to augment intestinal calcium absorption, but it is unclear through what molecular mechanism and whether dietary fiber has the same effects in older men. In this crossover intervention study, the investigators will enroll and follow 30 older male Veterans to evaluate the effects of soluble corn fiber on intestinal calcium absorption and explore the contribution of the gut microbiome.

Conditions

Aging

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Study Overview

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Study Details

Study overview

Osteoporotic fractures are a major but underrecognized problem in men. There is growing evidence that low dietary fiber intake is a modifiable risk factor for age-related bone loss in men. Preclinical and human studies in adolescents and postmenopausal women suggest that dietary fiber intake influences bone metabolism by modulating the gut microbiome to augment intestinal calcium absorption, but it is unclear through what molecular mechanism and whether dietary fiber has the same effects in older men. In this crossover intervention study, the investigators will enroll and follow 30 older male Veterans to evaluate the effects of soluble corn fiber on intestinal calcium absorption and explore the contribution of the gut microbiome.

Modulation of the Gut Microbiome by Dietary Fiber to Improve Calcium Absorption and Bone Health in Older Men

Fiber and Calcium Absorption in Older Men

Condition
Aging
Intervention / Treatment

-

Contacts and Locations

San Francisco

San Francisco VA Medical Center, San Francisco, CA, San Francisco, California, United States, 94121-1563

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Male Veterans 60 years of age
  • * History of malabsorption
  • * Hypercalcemia (corrected Ca \> 10.2 mg/dL)
  • * Vitamin D insufficiency (25OHD \< 30 ng/mL)
  • * Chronic kidney disease stage 3B or worse (CrCl \< 45 mL/min)
  • * Severe hypogonadism (AM fasting serum total testosterone \< 150 ng/dL)
  • * Daily use of proton pump inhibitor
  • * Use of medication(s) known to affect calcium metabolism
  • * Use of medications or supplements that could impact gut microbiota in the previous 3 months (antibiotics or commercially available probiotics or prebiotics.
  • * Presence of a condition or abnormality that in the opinion of the Investigator that would compromise the safety of the patient or the quality of the data.

Ages Eligible for Study

60 Years to

Sexes Eligible for Study

MALE

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

VA Office of Research and Development,

Karin C Wu, MD, PRINCIPAL_INVESTIGATOR, San Francisco VA Medical Center, San Francisco, CA

Study Record Dates

2029-01-01