RECRUITING

Acute Intermittent Hypoxia to Improve Airway Protection in Chronic Traumatic Brain Injury

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Acute intermittent hypoxia (AIH) involves 1-2min of breathing low oxygen air to stimulate neuroplasticity. Animal and human studies show that AIH improves motor function after neural injury, particularly when paired with task-specific training. Using a double blind cross-over study we will test whether AIH and task-specific airway protection training improves airway protection more than training alone in individuals with chronic mild-moderate traumatic brain injury (TBI).

Official Title

Acute Intermittent Hypoxia to Improve Airway Protection in Chronic Traumatic Brain Injury

Quick Facts

Study Start:2024-08-30
Study Completion:2025-07-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06520358

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:21 Years to 80 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Adults aged 21-80 years
  2. * A mild to moderate traumatic brain injury (TBI) confirmed by medical records
  3. * A Glasgow Coma Scale score between 9-15
  4. * Able to consent independently
  5. * Women of child-bearing age must be comfortable confirming a negative pregnancy prior to participating in the study
  1. * Other neurological diagnoses or a diagnosis of a severe psychiatric disorder
  2. * Severe aphasia preventing a participant from understanding the protocol and consent form
  3. * Pre-existing hypoxic pulmonary disease
  4. * History of obstructive lung diseases such as chronic obstructive pulmonary disease (COPD) or significant asthma)
  5. * Severe hypertension (\>160/100)
  6. * History of head and neck cancer
  7. * Allergy to barium sulfate
  8. * Ischemic cardiac disease

Contacts and Locations

Study Contact

Alicia Vose, Ph.D.
CONTACT
904-244-9092
Alicia.Vose@jax.ufl.edu
Maribel Z Ciampitti, M.S.
CONTACT
904-244-4674
maribel.ciampitti@jax.ufl.edu

Principal Investigator

Alicia Z Vose, Ph.D.
PRINCIPAL_INVESTIGATOR
University of Florida

Study Locations (Sites)

University of Florida
Jacksonville, Florida, 32209
United States

Collaborators and Investigators

Sponsor: University of Florida

  • Alicia Z Vose, Ph.D., PRINCIPAL_INVESTIGATOR, University of Florida

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-08-30
Study Completion Date2025-07-30

Study Record Updates

Study Start Date2024-08-30
Study Completion Date2025-07-30

Terms related to this study

Keywords Provided by Researchers

  • acute intermittent hypoxia
  • rehabilitation
  • airway protection
  • dysphagia

Additional Relevant MeSH Terms

  • Traumatic Brain Injury