Acute Intermittent Hypoxia to Improve Airway Protection in Chronic Traumatic Brain Injury

Description

Acute intermittent hypoxia (AIH) involves 1-2min of breathing low oxygen air to stimulate neuroplasticity. Animal and human studies show that AIH improves motor function after neural injury, particularly when paired with task-specific training. Using a double blind cross-over study we will test whether AIH and task-specific airway protection training improves airway protection more than training alone in individuals with chronic mild-moderate traumatic brain injury (TBI).

Conditions

Traumatic Brain Injury

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Study Overview

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Study Details

Study overview

Acute intermittent hypoxia (AIH) involves 1-2min of breathing low oxygen air to stimulate neuroplasticity. Animal and human studies show that AIH improves motor function after neural injury, particularly when paired with task-specific training. Using a double blind cross-over study we will test whether AIH and task-specific airway protection training improves airway protection more than training alone in individuals with chronic mild-moderate traumatic brain injury (TBI).

Acute Intermittent Hypoxia to Improve Airway Protection in Chronic Traumatic Brain Injury

Acute Intermittent Hypoxia to Improve Airway Protection in Chronic Traumatic Brain Injury

Condition
Traumatic Brain Injury
Intervention / Treatment

-

Contacts and Locations

Jacksonville

University of Florida, Jacksonville, Florida, United States, 32209

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Adults aged 21-80 years
  • * A mild to moderate traumatic brain injury (TBI) confirmed by medical records
  • * A Glasgow Coma Scale score between 9-15
  • * Able to consent independently
  • * Women of child-bearing age must be comfortable confirming a negative pregnancy prior to participating in the study
  • * Other neurological diagnoses or a diagnosis of a severe psychiatric disorder
  • * Severe aphasia preventing a participant from understanding the protocol and consent form
  • * Pre-existing hypoxic pulmonary disease
  • * History of obstructive lung diseases such as chronic obstructive pulmonary disease (COPD) or significant asthma)
  • * Severe hypertension (\>160/100)
  • * History of head and neck cancer
  • * Allergy to barium sulfate
  • * Ischemic cardiac disease

Ages Eligible for Study

21 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Florida,

Alicia Z Vose, Ph.D., PRINCIPAL_INVESTIGATOR, University of Florida

Study Record Dates

2025-07-30