A Dose Range-Finding Study to Assess the Efficacy and Safety of Multiple Dose Levels of AZD8630 in Adults With Uncontrolled Asthma at Risk of Exacerbations

Description

A dose range-finding study to assess the efficacy and safety of multiple dose levels of AZD8630 administered via a dry powder inhaler in adults with uncontrolled asthma at risk of exacerbations, receiving medium -to -high dose inhaled corticosteroid (ICS)/long-acting β2-agonist (LABA).

Conditions

Asthma

Study Overview

Study Details

Study overview

A dose range-finding study to assess the efficacy and safety of multiple dose levels of AZD8630 administered via a dry powder inhaler in adults with uncontrolled asthma at risk of exacerbations, receiving medium -to -high dose inhaled corticosteroid (ICS)/long-acting β2-agonist (LABA).

A Phase 2b, Randomised, Double-Blind, Placebo-Controlled Dose Range-Finding Study to Assess Efficacy and Safety of Multiple Dose Levels of Inhaled AZD8630 Given Once Daily for 12 Weeks in Adults With Uncontrolled Asthma at Risk of Exacerbations (LEVANTE)

A Dose Range-Finding Study to Assess the Efficacy and Safety of Multiple Dose Levels of AZD8630 in Adults With Uncontrolled Asthma at Risk of Exacerbations

Condition
Asthma
Intervention / Treatment

-

Contacts and Locations

Mesa

Research Site, Mesa, Arizona, United States, 85213

Huntington Beach

Research Site, Huntington Beach, California, United States, 92647

La Mesa

Research Site, La Mesa, California, United States, 91942

Laguna Niguel

Research Site, Laguna Niguel, California, United States, 92677

Lancaster

Research Site, Lancaster, California, United States, 93534

Long Beach

Research Site, Long Beach, California, United States, 90815

San Diego

Research Site, San Diego, California, United States, 92120

San Jose

Research Site, San Jose, California, United States, 95117

Aurora

Research Site, Aurora, Colorado, United States, 80045

Englewood

Research Site, Englewood, Colorado, United States, 80110

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

    Ages Eligible for Study

    18 Years to 80 Years

    Sexes Eligible for Study

    ALL

    Accepts Healthy Volunteers

    No

    Collaborators and Investigators

    AstraZeneca,

    Njira Lugogo, PRINCIPAL_INVESTIGATOR, Univeristy of Michigan Hospital, Ann Arbor, MI, US

    Study Record Dates

    2026-04-06