RECRUITING

Michigan Split-belt Treadmill Training Program to Improve Long-Term Knee Biomechanics After ACL Reconstruction

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this study is to gather pilot data to help inform a future clinical trial. As such, the investigators will employ a randomized clinical trial design, but data will only be collected on 9 total subjects. Nine subjects will be randomized to 2 split-belt intervention groups (one group where early stance loading is trained and the other where midstance loading is trained) and a placebo group. The goal of this study is to explore the adaptations in knee loading from a 6-week split-belt training intervention. The investigators' main question for this aim is: 1. Does knee loading, measured by the sagittal plane knee moment, change to a greater extent in the split-belt treadmill training groups compared to the placebo group? 2. Are there differences in training-related knee loading changes between individuals trained in the early stance vs. midstance loading split-belt training?

Official Title

Mi-SPA: Michigan Split-belt Adaptation Paradigm to Improve Knee Loading After Anterior Cruciate Ligament Reconstruction (Aim 3)

Quick Facts

Study Start:2025-08-13
Study Completion:2026-08
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06529692

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:14 Years to 45 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD, ADULT
Inclusion CriteriaExclusion Criteria
  1. * aged 14-45 years
  2. * suffered an acute, complete ACL rupture as confirmed by MRI and physical exam
  3. * have undergone ACL reconstruction w autograft within the past 10 months
  4. * willingness to participate in testing and follow-up as outlined in the protocol
  5. * English-speaking
  1. * inability to provide written informed consent
  2. * female subjects who are pregnant or are planning to become pregnant (self-reported)
  3. * previous ACL injury
  4. * previous surgery to either knee
  5. * bony fracture accompanying ACL injury
  6. * patients who experienced a knee dislocation
  7. * patients who had their ACL reconstructed with an allograft
  8. * patients who underwent a multi-ligamentous and/or staged ACL reconstruction

Contacts and Locations

Study Contact

Alexa Johnson, PhD
CONTACT
734-615-1297
akjohns@umich.edu
Riann M Palmieri-Smith, PhD, ATC
CONTACT
734-615-3154
riannp@umich.edu

Principal Investigator

Riann M Palmieri-Smith, PhD, ATC
PRINCIPAL_INVESTIGATOR
University of Michigan
Chandramouli Krishnan, PT, PhD
PRINCIPAL_INVESTIGATOR
University of Michigan

Study Locations (Sites)

University of Michigan
Ann Arbor, Michigan, 48176
United States

Collaborators and Investigators

Sponsor: University of Michigan

  • Riann M Palmieri-Smith, PhD, ATC, PRINCIPAL_INVESTIGATOR, University of Michigan
  • Chandramouli Krishnan, PT, PhD, PRINCIPAL_INVESTIGATOR, University of Michigan

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-08-13
Study Completion Date2026-08

Study Record Updates

Study Start Date2025-08-13
Study Completion Date2026-08

Terms related to this study

Keywords Provided by Researchers

  • Biomechanics
  • Knee Loading
  • Split-Belt Treadmill
  • Asymmetric Walking

Additional Relevant MeSH Terms

  • ACL
  • Anterior Cruciate Ligament
  • ACL Injury