RECRUITING

Michigan Split-belt Treadmill Training Program to Improve Long-Term Knee Biomechanics After ACL Reconstruction

Description

The goal of this study is to gather pilot data to help inform a future clinical trial. As such, the investigators will employ a randomized clinical trial design, but data will only be collected on 9 total subjects. Nine subjects will be randomized to 2 split-belt intervention groups (one group where early stance loading is trained and the other where midstance loading is trained) and a placebo group. The goal of this study is to explore the adaptations in knee loading from a 6-week split-belt training intervention. The investigators' main question for this aim is: 1. Does knee loading, measured by the sagittal plane knee moment, change to a greater extent in the split-belt treadmill training groups compared to the placebo group? 2. Are there differences in training-related knee loading changes between individuals trained in the early stance vs. midstance loading split-belt training?

Study Overview

Study Details

Study overview

The goal of this study is to gather pilot data to help inform a future clinical trial. As such, the investigators will employ a randomized clinical trial design, but data will only be collected on 9 total subjects. Nine subjects will be randomized to 2 split-belt intervention groups (one group where early stance loading is trained and the other where midstance loading is trained) and a placebo group. The goal of this study is to explore the adaptations in knee loading from a 6-week split-belt training intervention. The investigators' main question for this aim is: 1. Does knee loading, measured by the sagittal plane knee moment, change to a greater extent in the split-belt treadmill training groups compared to the placebo group? 2. Are there differences in training-related knee loading changes between individuals trained in the early stance vs. midstance loading split-belt training?

Mi-SPA: Michigan Split-belt Adaptation Paradigm to Improve Knee Loading After Anterior Cruciate Ligament Reconstruction (Aim 3)

Michigan Split-belt Treadmill Training Program to Improve Long-Term Knee Biomechanics After ACL Reconstruction

Condition
ACL
Intervention / Treatment

-

Contacts and Locations

Ann Arbor

University of Michigan, Ann Arbor, Michigan, United States, 48176

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * aged 14-45 years
  • * suffered an acute, complete ACL rupture as confirmed by MRI and physical exam
  • * have undergone ACL reconstruction w autograft within the past 10 months
  • * willingness to participate in testing and follow-up as outlined in the protocol
  • * English-speaking
  • * inability to provide written informed consent
  • * female subjects who are pregnant or are planning to become pregnant (self-reported)
  • * previous ACL injury
  • * previous surgery to either knee
  • * bony fracture accompanying ACL injury
  • * patients who experienced a knee dislocation
  • * patients who had their ACL reconstructed with an allograft
  • * patients who underwent a multi-ligamentous and/or staged ACL reconstruction

Ages Eligible for Study

14 Years to 45 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Michigan,

Riann M Palmieri-Smith, PhD, ATC, PRINCIPAL_INVESTIGATOR, University of Michigan

Chandramouli Krishnan, PT, PhD, PRINCIPAL_INVESTIGATOR, University of Michigan

Study Record Dates

2026-08