Skin Wetting in Burn Survivors

Description

This project will identify the efficacy of whole body skin wetting aimed to attenuate excessive elevations in internal body temperatures during physical activity in well-healed burn survivors. The investigators will conduct a randomized crossover design study. Non-burned control subjects, subjects who experienced burns covering \~20% to 40% of their body surface area, and subject having burns \>40% of their body surface area will be investigated. Subjects will exercise in heated environmental conditions while receiving no cooling or whole body skin wetting.

Conditions

Burn Injury

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Study Overview

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Study Details

Study overview

This project will identify the efficacy of whole body skin wetting aimed to attenuate excessive elevations in internal body temperatures during physical activity in well-healed burn survivors. The investigators will conduct a randomized crossover design study. Non-burned control subjects, subjects who experienced burns covering \~20% to 40% of their body surface area, and subject having burns \>40% of their body surface area will be investigated. Subjects will exercise in heated environmental conditions while receiving no cooling or whole body skin wetting.

Skin Wetting in Burn Survivors

Skin Wetting in Burn Survivors

Condition
Burn Injury
Intervention / Treatment

-

Contacts and Locations

Dallas

Institute for Exercise and Environmental Medicine, Dallas, Texas, United States, 75231

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Healthy male and female subjects
  • * 18-65 years of age.
  • * Free of any underlying medical conditions
  • * Any burn-related injuries resulting in at least one night of hospitalization.
  • * Heart disease or any other chronic medical condition requiring regular medical therapy including cancer, diabetes, and hypertension.
  • * Abnormalities detected on routine screening
  • * Individuals who participate in a structured aerobic exercise training program at moderate to high intensities.
  • * Current smokers, as well as individuals who regularly smoked within the past 3 years.
  • * Body mass index of greater than 30 kg/m\^2.
  • * Pregnant individuals
  • * Healthy male and female subjects
  • * 18-65 years of age.
  • * Free of any underlying medical conditions
  • * Having a burn injury covering 20-40% or \>40% of the participant's body surface area; at least 50% of those burn injuries must be full thickness that required skin grafting.
  • * Participants must have been hospitalized due to the burn injury for a minimum of 15 days
  • * Any burn-related injuries resulting in at least one night of hospitalization.
  • * Heart disease or any other chronic medical condition requiring regular medical therapy including cancer, diabetes, and hypertension.
  • * Abnormalities detected on routine screening
  • * Individuals who participate in a structured aerobic exercise training program at moderate to high intensities.
  • * Current smokers, as well as individuals who regularly smoked within the past 3 years.
  • * Body mass index of greater than 30 kg/m\^2.
  • * Pregnant individuals
  • * Extensive unhealed injured skin

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Texas Southwestern Medical Center,

Study Record Dates

2026-07-31