Real-time Personalized Brain State-dependent TMS After Stroke

Description

Transcranial magnetic stimulation (TMS) interventions could feasibly strengthen residual corticospinal tract (CST) connections and enhance recovery of paretic hand function after stroke. This project will test whether personalized brain state-dependent TMS can activate the residual corticospinal tract better than standard TMS, and evaluate the relationship between this activation and hand motor impairment.

Conditions

Stroke

Talk to us

Study Overview

On this page

Study Details

Study overview

Transcranial magnetic stimulation (TMS) interventions could feasibly strengthen residual corticospinal tract (CST) connections and enhance recovery of paretic hand function after stroke. This project will test whether personalized brain state-dependent TMS can activate the residual corticospinal tract better than standard TMS, and evaluate the relationship between this activation and hand motor impairment.

Towards Real-time Personalized Brain State-dependent TMS to Enhance Poststroke Hand Rehabilitation

Real-time Personalized Brain State-dependent TMS After Stroke

Condition
Stroke
Intervention / Treatment

-

Contacts and Locations

Austin

University of Texas at Austin, Austin, Texas, United States, 78712

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * History of stroke \>6 months ago
  • * Presence of residual upper extremity hemiparesis
  • * Willingness to participate
  • * Ability to provide informed consent
  • * Upper extremity Fugl-Meyer score \< 66
  • * Mini Mental State Exam score \> 24
  • * Discernable and reliable motor-evoked potential (MEP) following single-pulse transcranial magnetic stimulation to the lesioned hemisphere
  • * History of neurological disease and/or neurological injury other than stroke
  • * Presence of contraindications to transcranial magnetic stimulation (TMS) or peripheral nerve stimulation (PNS) including: cardiac pacemaker, cochlear implant, cortical stimulator, deep brain stimulator, vagus nerve stimulator, cervical spine epidural stimulator, and/or ventriculoperitoneal shunt, ferromagnetic metallic implants above the level of the seventh cervical vertebrae, seizure in the last 12 months while taking anti-epilepsy medication, history of adverse reactions to TMS or PNS
  • * current, suspected, or planned pregnancy
  • * recent changes (within the last month) to medication use
  • * Upper extremity Fugl-Meyer score = 66
  • * Mini Mental State Exam score \<= 24
  • * No discernible or reliable MEP elicited following single-pulse TMS to the lesioned hemisphere

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Texas at Austin,

Study Record Dates

2026-08-31