Lung Function Monitoring During Hypoxemia Episodes

Description

Premature infants commonly have desaturation episodes due to different reasons such as cessation of breathing or loss of lung volume. The purpose of this study is to differentiate the mechanisms of desaturation episodes with continuous lung volume monitoring. As we better understand the mechanisms underlying the desaturation episodes, newer strategies directed at underlying pathophysiology can potentially by evaluated for mitigation of these episodes.

Conditions

Hypoxemia of Newborn

Study Overview

Study Details

Study overview

Premature infants commonly have desaturation episodes due to different reasons such as cessation of breathing or loss of lung volume. The purpose of this study is to differentiate the mechanisms of desaturation episodes with continuous lung volume monitoring. As we better understand the mechanisms underlying the desaturation episodes, newer strategies directed at underlying pathophysiology can potentially by evaluated for mitigation of these episodes.

Differentiating Pathophysiological Mechanisms of Hypoxemia Episodes by Continuous Lung Function Monitoring in Preterm Infants

Lung Function Monitoring During Hypoxemia Episodes

Condition
Hypoxemia of Newborn
Intervention / Treatment

-

Contacts and Locations

New Brunswick

Bristol Myers Squibbs Childrens Hospital, New Brunswick, New Jersey, United States, 08901

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Born at ≤32w GA
  • * Post menstrual age between 30w to 36w
  • * 4 or more episodes of HEs in the previous 24h (Defined as SpO2\<90≥5s)
  • * Major congenital malformation
  • * Receiving invasive mechanical ventilation
  • * Severe neurological injury
  • * Hemodynamic instability requiring inotropes in last 72h

Ages Eligible for Study

to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Rutgers, The State University of New Jersey,

Deepak Jain, MD, PRINCIPAL_INVESTIGATOR, Rutgers Robert Wood Johnson Medical School Department of Pediatrics

Study Record Dates

2026-08-04