Respiratory Training in Friedreich's Ataxia

Description

This is a prospective interventional study of patients with Friedreich's Ataxia that receive respiratory strength training for a period of 12 weeks with two research visits at the beginning and at the end of the study period. Visits include swallowing evaluation with fiberoptic endoscopic evaluation of swallowing, pulmonary function testing, surface electromyography and patient surveys.

Conditions

Friedreich Ataxia

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Study Overview

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Study Details

Study overview

This is a prospective interventional study of patients with Friedreich's Ataxia that receive respiratory strength training for a period of 12 weeks with two research visits at the beginning and at the end of the study period. Visits include swallowing evaluation with fiberoptic endoscopic evaluation of swallowing, pulmonary function testing, surface electromyography and patient surveys.

Impact of Respiratory Training in Swallowing and Respiratory Function in Patients With Friedreich's Ataxia

Respiratory Training in Friedreich's Ataxia

Condition
Friedreich Ataxia
Intervention / Treatment

-

Contacts and Locations

Gainesville

Clinical Research Center, Gainesville, Florida, United States, 32610

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * confirmed genetic testing of Friedreich's Ataxia
  • * have an overall DIGEST score of 1 or higher based on FEES screening
  • * are able to perform pulmonary function testing
  • * have been on antibiotics within 15 days prior to baseline screening.
  • * have been prescribed systemic corticosteroids or neuromuscular blocking agents within 15 days of the baseline screening
  • * have an allergy or contraindication to topical lidocaine or oxymetazoline
  • * have any other concurrent medical condition which, in the opinion of the investigators, would make the subject inappropriate to participate in testing or respiratory exercise

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Florida,

Carmen Leon Astudillo, MD, PRINCIPAL_INVESTIGATOR, University of Florida

Study Record Dates

2025-03