Effect of Transcutaneous Electrical Nerve Stimulation on Post-stroke Patients

Description

The subjects will be asked to attend minimum 15 separate sessions, 6 for testing changes in reflex behaviors, 3 for testing changes in the influence of descending motor tracts on spinal motor neurons, 3 for each testing functional movement in response to a trip event and cross-tilt walking adaptation pattern, as part of their participation in the research study. The estimated amount of time to enroll and collect the data for each of the subjects is four months' time. The data will be analyzed and ready for grant preparation (if successful) in approximately four months after the start of the study.

Conditions

Hemiplegia and/or Hemiparesis Following Stroke, Anterior Circulation Stroke of Uncertain Pathology

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Study Overview

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Study Details

Study overview

The subjects will be asked to attend minimum 15 separate sessions, 6 for testing changes in reflex behaviors, 3 for testing changes in the influence of descending motor tracts on spinal motor neurons, 3 for each testing functional movement in response to a trip event and cross-tilt walking adaptation pattern, as part of their participation in the research study. The estimated amount of time to enroll and collect the data for each of the subjects is four months' time. The data will be analyzed and ready for grant preparation (if successful) in approximately four months after the start of the study.

TENS (Transcutaneous Electrical Nerve Stimulation): Effect of Transcutaneous Spinal Direct Current Stimulation on Lower Limb Reflex, Volitional, and Functional Movement Post-stroke

Effect of Transcutaneous Electrical Nerve Stimulation on Post-stroke Patients

Condition
Hemiplegia and/or Hemiparesis Following Stroke
Intervention / Treatment

-

Contacts and Locations

Dallas

University of Texas Medical Center, Dallas, Texas, United States, 75390

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * History of single unilateral stroke with subsequent lower limb hemiparesis on either side (\> 6 months since onset)
  • * Ability to walk as part of activities of daily living
  • * Age between 18 and 80
  • * Presence of concurrent severe medical illness including unhealed pressure sore, active or untreated infection, thromboembolic disease, severe contracture, osteoporosis, heterotropic classification, lower limb fracture, severe pulmonary disease or cardiovascular instability, uncontrolled seizure, uncontrolled diabetes
  • * History of any neurological injury other than a single stroke
  • * Has received a Botox injection in the lower extremity within the last 4 months
  • * Any cognitive deficit that would prevent informed consent or ability to perform the experiment
  • * History of prior injury or surgery to the hip or knee
  • * Presence of significant lower extremity edema - Presence of cardiac pacemaker or any other electrically implanted device - Use of braces limiting harness/Lokomat fit (Any spinal orthoses such as TLSO, HALO)
  • * Weight greater than 300 pounds
  • * Adults unable to consent, infants, children, teenagers, pregnant women and prisoners will not be included in the study
  • * Clinically significant depression, psychiatric disorders, or ongoing drug abuse
  • * Actively taking medications with agents known to increase (e.g. amphetamines) or decrease motor system excitability
  • * Suffered a concussion in the last 6 months.
  • * Unexplained headaches

Ages Eligible for Study

18 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Texas Southwestern Medical Center,

Yasin Dhaher, Ph.D., PRINCIPAL_INVESTIGATOR, University of Texas Southwestern Medical Center

Study Record Dates

2025-12-31