Safety and Impact of Low Resistance Exercise Training on Quality of Life in Pulmonary Arterial Hypertension

Description

The purpose of the study is to learn more about how low-resistance training impacts frailty and the quality of life of people with pulmonary arterial hypertension (PAH). Low-resistance training is an evidence-based approach that may help patients improve their functional ability.

Conditions

Pulmonary Arterial Hypertension, Frailty

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Study Overview

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Study Details

Study overview

The purpose of the study is to learn more about how low-resistance training impacts frailty and the quality of life of people with pulmonary arterial hypertension (PAH). Low-resistance training is an evidence-based approach that may help patients improve their functional ability.

Safety and Impact of Low Resistance Exercise Training on Quality of Life in Pulmonary Arterial Hypertension

Safety and Impact of Low Resistance Exercise Training on Quality of Life in Pulmonary Arterial Hypertension

Condition
Pulmonary Arterial Hypertension
Intervention / Treatment

-

Contacts and Locations

Philadelphia

University of Pennsyvania, Philadelphia, Pennsylvania, United States, 19103

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Diagnosis of PAH: idiopathic, heritable, associated with connective tissue disease, congenital heart disease, human immunodeficiency virus, drug- or toxin, or portopulmonary hypertension
  • * On stable PAH therapy for 3 months
  • * World Health Organization (WHO) functional class IV
  • * Left ventricular ejection fraction \< 40% (via transthoracic echocardiogram (TTE) within one year of screening)
  • * Moderate or severe concomitant lung disease: Chronic Obstructive Pulmonary Disease (COPD) or interstitial lung disease
  • * Enrollment in a clinical trial
  • * Recent hospitalization (within 4 weeks of screening)
  • * Inability to perform the Short Physical Performance Battery or wheelchair bound

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Pennsylvania,

Nadine Al-Naamani, MD, MS, PRINCIPAL_INVESTIGATOR, University of Pennsylvania

Study Record Dates

2025-10-01