Cognitive Rehabilitation Following Breast Cancer Treatment

Description

The goal of this proposed project is to evaluate the feasibility and preliminary effect of metacognitive strategy training to improve activity performance, cognition, and quality of life in breast cancer survivors with cancer-related cognitive impairment (CRCI). The other goal of this proposed project is to examine the effects of CO-OP on resting (rsFC)- and task-state functional connectivity as compared to an inactive control group.

Conditions

Breast Cancer Female

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Study Overview

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Study Details

Study overview

The goal of this proposed project is to evaluate the feasibility and preliminary effect of metacognitive strategy training to improve activity performance, cognition, and quality of life in breast cancer survivors with cancer-related cognitive impairment (CRCI). The other goal of this proposed project is to examine the effects of CO-OP on resting (rsFC)- and task-state functional connectivity as compared to an inactive control group.

Pilot Testing of Metacognitive Strategy Training to Address Cancer-related Cognitive Impairment in Breast Cancer

Cognitive Rehabilitation Following Breast Cancer Treatment

Condition
Breast Cancer Female
Intervention / Treatment

-

Contacts and Locations

Columbia

University of Missouri, Columbia, Missouri, United States, 65211

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * self-reported CRCI (Global Rating of Cognition dysfunction as "Moderately" "Strongly "or "Extremely" AND a Cognitive Failures Questionnaire1 (CFQ) score \>30)
  • * completed treatment for active cancer diagnosis (invasive ductal or lobular BrCA Stages I, II, or III) at least 6 months but not greater than 3 years prior to participation
  • * able to read, write, and speak English fluently
  • * able to provide valid informed consent
  • * have a life expectancy of greater than 6 months at time of enrollment
  • * on stable doses (i.e., no changes in past 90 days) of medications that are known to impact cognitive function (i.e., anti-depressants)
  • * prior cancer diagnoses of other sites with evidence of active disease within the past year
  • * active diagnoses of any acute or chronic brain-related neurological conditions that can alter normal brain anatomy or function (e.g., Parkinson's disease, dementia, cerebral infarcts) dementia symptoms as indicated by a score of \<23 on the Montreal Cognitive Assessment (MoCA)
  • * severe depressive symptoms (Personal Health Questionnaire-9 (PHQ-9) score of ≥21)
  • * history of severe traumatic brain injury, prolonged loss of consciousness (e.g., coma)
  • * conditions contraindicated for MRI (e.g., electrical implants, pumps, claustrophobia)
  • * blue-yellow colorblindness
  • * pregnancy

Ages Eligible for Study

20 Years to 75 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Missouri-Columbia,

Anna E Boone, PhD, OTR/L, PRINCIPAL_INVESTIGATOR, University of Missouri Occupational Therapy

Study Record Dates

2025-12-30