RECRUITING

Study of XB010 in Subjects With Solid Tumors

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This is a FIH study is to evaluate the safety, tolerability, PK, immunogenicity, and preliminary antitumor activity of XB010 as a single agent and in combination with pembrolizumab in subjects with locally advanced or metastatic solid tumors for whom alternative therapies do not exist or available therapies are intolerable or no longer effective.

Official Title

A Dose-Escalation and Expansion Study of XB010 as a Single Agent and Combination Therapy in Subjects With Locally Advanced or Metastatic Solid Tumors

Quick Facts

Study Start:2024-08-06
Study Completion:2027-10-20
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06545331

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Exelixis Clinical Trials
CONTACT
1-888-EXELIXIS (888-393-5494)
druginfo@exelixis.com
Backup or International
CONTACT
650-837-7400

Study Locations (Sites)

Exelixis Clinical Site #4
Duarte, California, 91010
United States
Exelixis Clinical Site #3
Huntersville, North Carolina, 28078
United States
Exelixis Clinical Site #1
Austin, Texas, 78758
United States
Exelixis Clinical Site #2
Fairfax, Virginia, 22031
United States

Collaborators and Investigators

Sponsor: Exelixis

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-08-06
Study Completion Date2027-10-20

Study Record Updates

Study Start Date2024-08-06
Study Completion Date2027-10-20

Terms related to this study

Additional Relevant MeSH Terms

  • Locally Advanced or Metastatic Solid Tumors