Gut Microbiota-dependent Health Impacts of Haskap Berries

Description

Polyphenol-rich Haskap berries (Haskap) have untapped therapeutic potential to improve human health, and agricultural producers in northern U.S. states are poised to increase production if consumer demand increases. A critical knowledge gap is that little is known about the interactions between gut microbes and Haskap polyphenols to produce bioactive metabolites linked to downstream health impacts. Additionally, little is known about which Haskap varieties and harvest timing yield the greatest bioactive potential. This study aims to address these gaps by investigating the interaction of bioactive components in Haskap with gut microbiota and the resultant gut and serum metabolites, inflammation, and metabolic health, and then couple this with analysis of berries from different Haskap varieties and harvest times.

Conditions

Metabolic Disease, Inflammation, Microbial Colonization

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Study Overview

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Study Details

Study overview

Polyphenol-rich Haskap berries (Haskap) have untapped therapeutic potential to improve human health, and agricultural producers in northern U.S. states are poised to increase production if consumer demand increases. A critical knowledge gap is that little is known about the interactions between gut microbes and Haskap polyphenols to produce bioactive metabolites linked to downstream health impacts. Additionally, little is known about which Haskap varieties and harvest timing yield the greatest bioactive potential. This study aims to address these gaps by investigating the interaction of bioactive components in Haskap with gut microbiota and the resultant gut and serum metabolites, inflammation, and metabolic health, and then couple this with analysis of berries from different Haskap varieties and harvest times.

PARTNERSHIP: Elucidating Gut Microbiota-dependent Health Impacts of Haskap Berries to Inform Agricultural Production Practices That Will Maximize Bioactive Potential

Gut Microbiota-dependent Health Impacts of Haskap Berries

Condition
Metabolic Disease
Intervention / Treatment

-

Contacts and Locations

Bozeman

Montana State University, Bozeman, Montana, United States, 59717

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * BMI \<18 or \> 40 kg/m\^2
  • * potential allergy to Haskap or placebo ingredients
  • * use of anti-inflammatory, lipid lowering, glucose lowering, blood pressure, or any other medications that may interfere with study measures
  • * pregnant or lactating woman
  • * diagnosis with type 1 or type 2 diabetes or any other condition that may interfere with study measures
  • * smoke cigarettes
  • * have taken antibiotics in the past 90 days
  • * take supplements including pre/probiotics or "superfoods" within 30 days of starting the study
  • * are planning on starting a weight loss or exercise regiment change
  • * follow a specific diet such as low carbohydrate, vegan, and vegetarian
  • * consume over 5 servings of fruit/vegetables per day
  • * are unwilling to reduce caffeine intake to one 8 oz serving per day for the durations of the study

Ages Eligible for Study

35 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Montana State University,

Mary P Miles, PhD, PRINCIPAL_INVESTIGATOR, Montana State University

Study Record Dates

2028-05