The Spastic Paraplegia - Centers of Excellence Research Network (SP-CERN) is a collaborative research consortium dedicated to advancing the understanding, diagnosis, and treatment of hereditary spastic paraplegia (HSP) and primary lateral sclerosis (PLS). Aims of the consortium are to a) perform natural history studies of HSP subtypes, b) discover and validate biomarkers and clinician- and patient-reported outcome measures, c) uncover HSP's molecular pathophysiology and develop rational therapeutic targets, and d) perform sufficiently powered clinical trials. The current pilot study is aimed at enrolling 100 individuals with hereditary spastic paraplegia type 4 (SPG4) or hereditary spastic paraplegia type 5A (SPG5A).
Hereditary Spastic Paraplegia, Primary Lateral Sclerosis, SPG4, SPG5A, Spastic Paraplegia 4, Spastic Paraplegia 5A, Early Onset Hereditary Spastic Paraplegia, Neuromuscular Diseases, Spastic Paraplegia, Hereditary
The Spastic Paraplegia - Centers of Excellence Research Network (SP-CERN) is a collaborative research consortium dedicated to advancing the understanding, diagnosis, and treatment of hereditary spastic paraplegia (HSP) and primary lateral sclerosis (PLS). Aims of the consortium are to a) perform natural history studies of HSP subtypes, b) discover and validate biomarkers and clinician- and patient-reported outcome measures, c) uncover HSP's molecular pathophysiology and develop rational therapeutic targets, and d) perform sufficiently powered clinical trials. The current pilot study is aimed at enrolling 100 individuals with hereditary spastic paraplegia type 4 (SPG4) or hereditary spastic paraplegia type 5A (SPG5A).
Spastic Paraplegia - Centers of Excellence Research Network
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University of Miami Miller School of Medicine, Miami, Florida, United States, 33136
University of Iowa Carver College of Medicine, Iowa City, Iowa, United States, 52242
Boston Children's Hospital, Boston, Massachusetts, United States, 02215
Massachusetts General Hospital, Boston, Massachusetts, United States, 02215
University of Michigan School of Medicine, Ann Arbor, Michigan, United States, 48109
Columbia University - Irving Medical Center, New York, New York, United States, 10032
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States, 45229-3039
Scottish Rite for Children, Dallas, Texas, United States, 75219
Texas Children's Hospital, Houston, Texas, United States, 77035
Seattle Children's Hospital, Seattle, Washington, United States, 98105
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
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Boston Children's Hospital,
2027-06-04