COMPLETED

Activating the Cholinergic Anti-Inflammatory Pathway in Healthy Volunteers and People With Inflammatory Arthritis

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study is designed to investigate whether non-invasive ultrasound (US) that is optimized for stimulation and can elicit an anti-inflammatory response in people with Inflammatory Arthritis as compared to a sham intervention. The primary endpoint is the change in pro-inflammatory cytokines in blood drawn before and after US. Each participant receives 4 experimental US sessions, one of which is randomly assigned to be placebo.

Official Title

Activating the Cholinergic Anti-Inflammatory Pathway With Focused Ultrasound Stimulation in Healthy Volunteers and People With Inflammatory Arthritis

Quick Facts

Study Start:2025-10-01
Study Completion:2026-01-05
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT06555562

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:22 Years to 75 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * 22-75 years of age
  2. * Weigh at least 40 kg
  1. * Any physical disabilities, conditions, or diseases that limit the capacity to participate in study procedures or increase the risk of harm as determined by the study PI
  2. * Unable to provide informed consent
  3. * Active bacterial or viral infection
  4. * Class II obesity with a BMI of 35 or higher
  5. * Pregnant women or those trying to become pregnant
  6. * Active use of tobacco/nicotine products
  7. * History of substance use disorder or active regular use of substances (nicotine, marijuana, cocaine, psychedelics, stimulants, etc.)
  8. * Splenomegaly, asplenia, or splenectomy

Contacts and Locations

Study Locations (Sites)

Tekton Research
Austin, Texas, 78745
United States
UT Health
Houston, Texas, 77030
United States

Collaborators and Investigators

Sponsor: Surf Therapeutics

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-10-01
Study Completion Date2026-01-05

Study Record Updates

Study Start Date2025-10-01
Study Completion Date2026-01-05

Terms related to this study

Additional Relevant MeSH Terms

  • Psoriatic Arthritis
  • Rheumatoid Arthritis
  • Ankylosing Spondylitis