Registry for Esophageal and Gastroesophageal Junction Cancer

Eligibility Criteria

• * Newly diagnosed stage IV adenocarcinoma of the esophagus or GEJ with OMD at the time of diagnosis, defined as the following:
• * Retroperitoneal lymph nodes (e.g., para-aortal, intra-aorto-caval, parapancreatic, or mesenterial lymph node)
• * Liver
• * Lung
• * Extra-abdominal lymph nodes (e.g., supraclavicular or cervical lymph nodes)
• * Adrenal gland
• * Unilateral or bilateral ovarian metastases (in the absence of gross or microscopic peritoneal disease \[positive cytology\])
• * Bone
• * ≤2 sites of disease (excluding the primary tumor and regional lymph nodes)
• * ≤3 tumors within each organ system
• * ≤5 metastases
• * All nonregional lymph nodes (including cervical, supraclavicular, and retroperitoneal nodal disease) are considered 1 discrete lesion
• * Satellite lesions in the primary esophageal malignancy, such as skipped esophageal primaries, are not considered metastatic sites
• * All sites of disease must be amenable to complete local therapy after systemic therapy, according to the treating physician. Treatment modalities include:
• * Surgery
• * Definitive chemoradiation
• * Stereotactic radiation
• * Ablation or similar techniques (e.g., irreversible electroporation)
• * Age ≥18 years
• * Presence of metastases, at the time of diagnosis, to the following:
• * Peritoneum, including positive peritoneal lavage (on the basis of baseline diagnostic laparoscopy to rule out gross disease and positive peritoneal lavage cytology; laparoscopy may be omitted for patients in whom all sites of disease are above the diaphragm)
• * Malignant pleural effusion
• * Brain metastases or leptomeningeal disease
• * Other sites not specifically noted must be reviewed and approved by the PIs
• * Any site of disease that is not amenable to definitive local therapy
• * Unfit for best systemic therapy
• * Metachronous OMD
• * Secondary primary cancer, with the exclusion of basal cell carcinoma of the skin
• * Pregnant, lactating, or intending to become pregnant
• * Unwilling to provide informed consent