IV vs Epidural Opioids + Epidural Local Anesthetic for Laparotomy Analgesia

Description

The purpose of this research study is to determine if the two common ways of administering additional opioids (morphine like substance, narcotic) with an epidural, either mixed in the epidural solution or given separately through the intravenous, are equally effective in controlling post-operative pain

Conditions

Laparotomy

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Study Overview

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Study Details

Study overview

The purpose of this research study is to determine if the two common ways of administering additional opioids (morphine like substance, narcotic) with an epidural, either mixed in the epidural solution or given separately through the intravenous, are equally effective in controlling post-operative pain

Randomized Controlled Study Comparing the Administration of Opioids Epidurally vs IV in Patients Undergoing Laparotomy With an Epidural for Post-Operative Analgesia

IV vs Epidural Opioids + Epidural Local Anesthetic for Laparotomy Analgesia

Condition
Laparotomy
Intervention / Treatment

-

Contacts and Locations

Iowa City

University of Iowa Health Care, Iowa City, Iowa, United States, 52242

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Age including and between 18 to 85 years old
  • 2. Planned open abdominal procedure with an incision that is or includes above the umbilicus, where epidural would normally be offered and epidural would be maintained for an average of 4 to 5 days
  • 3. Patient has consented for an epidural
  • 4. Patient is able to converse in English
  • 5. Patient is able to use a patient controlled pump
  • 1. Has a known contraindication for an epidural
  • 2. Known mental or cognitive disability
  • 3. History of chronic opioid use or substance abuse disorder
  • 4. Pre-operative use of opioids
  • 5. History of chronic pain
  • 6. Routine use of marijuana
  • 7. Incarcerated
  • 8. Unable to converse in English
  • 9. Planned to remain intubated post-operatively
  • 10. Need for post-operative use of anticoagulant regiment that would be contraindicated with an indwelling epidural catheter
  • 11. End stage renal disease or dialysis
  • 12. Hepatic disease that affects metabolism of drugs
  • 13. Known contraindication to any of the study drugs
  • 14. Known pregnancy or positive pre-operative pregnancy test
  • 15. Known neurological condition that may affect motor or sensory systems

Ages Eligible for Study

18 Years to 85 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Iowa,

Melinda Seering, MD, PRINCIPAL_INVESTIGATOR, Univeristy of Iowa

Study Record Dates

2024-12-30