Study of Enhanced Programming Stimulation with the Enterra® Therapy System

Description

The purpose of this research study is to evaluate if an enhanced Enterra device programming strategy will improve symptoms associated with gastroparesis, improve symptoms in a faster amount of time, and improve quality of life measures. Participants in this study will be evaluated for study entry criteria, have an Enterra Therapy System implanted, and be randomly assigned to one of two programming strategies. Participants will answer daily questions about their gastroparesis symptoms on an application with their phone/tablet. Participants will answer quality of life questionnaires about their gastroparesis symptoms at monthly study visits. Participants will be involved in the study for up to six months after treatment assignment. Programming parameters in the study are within currently approved labeling.

Conditions

Gastroparesis, Gastroparesis Nondiabetic, Gastroparesis Due to Diabetes Mellitus

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Study Overview

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Study Details

Study overview

The purpose of this research study is to evaluate if an enhanced Enterra device programming strategy will improve symptoms associated with gastroparesis, improve symptoms in a faster amount of time, and improve quality of life measures. Participants in this study will be evaluated for study entry criteria, have an Enterra Therapy System implanted, and be randomly assigned to one of two programming strategies. Participants will answer daily questions about their gastroparesis symptoms on an application with their phone/tablet. Participants will answer quality of life questionnaires about their gastroparesis symptoms at monthly study visits. Participants will be involved in the study for up to six months after treatment assignment. Programming parameters in the study are within currently approved labeling.

Examination of Programming with the Enterra® Therapy System in a Double-Blinded, Randomized, Prospective Study in the Treatment of Nausea and Vomiting Symptoms Using Gastric Electrical Stimulation

Study of Enhanced Programming Stimulation with the Enterra® Therapy System

Condition
Gastroparesis
Intervention / Treatment

-

Contacts and Locations

Tampa

University of South Florida, Tampa, Florida, United States, 33620

Louisville

University of Louisville, Louisville, Kentucky, United States, 40202

Detroit

Henry Ford Health System, Detroit, Michigan, United States, 48202

Saint Louis

Washington University, Saint Louis, Missouri, United States, 63110

Portland

Foundation for Surgical Innovation, Portland, Oregon, United States, 97213

Seattle

Benaroya Research Institute at Virginia Mason, Seattle, Washington, United States, 98101

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Completed informed consent process with signed and dated informed consent form
  • 2. Stated willingness to comply with all study procedures and availability for the duration of the study
  • 3. Male or female, aged ≥18 or ≤70 years at time of Enterra® therapy implantation
  • 4. Diagnosed with idiopathic or diabetic gastroparesis
  • 5. Delayed solid-phase gastric emptying study (Eggbeaters™ test meal), completed within one year of patient enrollment in the study. Gastroparesis defined as \> 60% retained at 2 hours and/or \>10% retained at 4 hours
  • 6. Investigator confirms normal endoscopy within one year of enrollment in the study
  • 7. GCSI-DD score for nausea severity during the qualifying Baseline Period averaging 2.5 or more per week and vomiting averaging 5 or more episodes per week
  • 1. Post-surgical gastroparesis (e.g., fundoplication, Billroth I or II) or other active stomach or gastrointestinal diseases disorders which could explain symptoms in the opinion of the investigator
  • 2. History of pyloroplasty or pyloromyotomy or G-POEM
  • 3. Pregnancy or breastfeeding at the time of consent, or intent to become pregnant during the study
  • 4. Active H. pylori infection
  • 5. Significant hepatic injury (elevated ALT, AST, bilirubin)
  • 6. Metabolic, mechanical, or mucosal inflammatory causes that may explain GI symptoms such as gallbladder disease, small bowel bacterial overgrowth, IBS, inflammatory bowel disease, celiac disease, liver or pancreatic disease, or bowel obstruction
  • 7. Patients with significant cardiac or cardiovascular disease, malignancy, or other conditions
  • 8. Participation in other clinical studies
  • 9. Use of narcotics more than three days per week or other drugs that may affect motility (e.g., Glucagon-like peptide 1 (GLP-1) agonist drug)
  • 10. Cannabis and/or cannabinoid use that exceeds either:
  • 1. Greater than 3 days of usage per week with 2 or less occurrences each day of use, or
  • 2. Greater than 3 grams of total usage per week
  • 11. Previous diagnosis or history of orthostatic intolerance, e.g., POTS, neurocardiogenic syncope, orthostatic hypotension
  • 12. Subject experiences discomfort during stimulation assessment that cannot be tolerated
  • 13. Subjects with an underlying disease leading to follow-up by MRI outside of current MR conditional indications
  • 14. Evidence of a failed response to temporary gastric electrical stimulation

Ages Eligible for Study

18 Years to 70 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Enterra Medical, Inc.,

Michael Awad, MD, PhD, PRINCIPAL_INVESTIGATOR, Washington University School of Medicine

Study Record Dates

2026-12