A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%

Description

The purpose of this study is to compare the efficacy of Nivolumab and Relatlimab in combination with chemotherapy to Pembrolizumab with Chemotherapy in participants with stage IV or recurrent Non-squamous Non-small Cell Lung Cancer with PD-L1 expression ≥ 1%

Conditions

Non-small Cell Lung Cancer

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Study Overview

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Study Details

Study overview

The purpose of this study is to compare the efficacy of Nivolumab and Relatlimab in combination with chemotherapy to Pembrolizumab with Chemotherapy in participants with stage IV or recurrent Non-squamous Non-small Cell Lung Cancer with PD-L1 expression ≥ 1%

A Phase 3, Randomized, Open-label Study of Nivolumab + Relatlimab Fixed-dose Combination With Chemotherapy Versus Pembrolizumab With Chemotherapy as First-line Treatment for Participants With Non-squamous (NSQ), Stage IV or Recurrent Non-small Cell Lung Cancer and With Tumor Cell PD-L1 Expression ≥ 1%

A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%

Condition
Non-small Cell Lung Cancer
Intervention / Treatment

-

Contacts and Locations

Tucson

Local Institution - 0368, Tucson, Arizona, United States, 85723

Los Angeles

Local Institution - 0111, Los Angeles, California, United States, 90404

Los Angeles

Local Institution - 0112, Los Angeles, California, United States, 90404

Sacramento

Local Institution - 0304, Sacramento, California, United States, 95817

San Francisco

Local Institution - 0159, San Francisco, California, United States, 94115

Miami

Local Institution - 0206, Miami, Florida, United States, 33136

Pembroke Pines

Local Institution - 0162, Pembroke Pines, Florida, United States, 33028

Saint Petersburg

Local Institution - 0358, Saint Petersburg, Florida, United States, 33705

West Palm Beach

Local Institution - 0360, West Palm Beach, Florida, United States, 33401

Edgewood

Saint Elizabeth Medical Center Edgewood, Edgewood, Kentucky, United States, 41017

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

    Ages Eligible for Study

    18 Years to

    Sexes Eligible for Study

    ALL

    Accepts Healthy Volunteers

    No

    Collaborators and Investigators

    Bristol-Myers Squibb,

    Bristol-Myers Squibb, STUDY_DIRECTOR, Bristol-Myers Squibb

    Study Record Dates

    2033-11-11