RECRUITING

CYP2D6 Genotype-guided Management of Opioid Analgesics in Patients Undergoing Elective Ventral Hernia Repairs

Conditions

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Pilot pragmatic trial using an implementation science approach to determine the feasibility of a CYP2D6-guided opioid prescribing for patients undergoing elective VHRs compared to usual care. Assess the efficacy (PROMIS Pain Intensity and Hernia-Related QOL) of a CYP2D6-guided opioid prescribing approach for patients undergoing elective VHRs.

Official Title

Feasibility and Efficacy of CYP2D6 Genotype-guided Management of Opioid Analgesics in Patients Undergoing Elective Ventral Hernia Repairs: A Pilot Pragmatic Trial

Quick Facts

Study Start:2025-01-29
Study Completion:2026-07
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06565546

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 90 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * \> 18 years age undergoing a ventral hernia repair (VHR) ≥1.5 cm in diameter with mesh.
  1. * ventral hernia \<1.5 cm
  2. * primary ventral hernia repair (VHR) without a mesh
  3. * emergency operative procedure
  4. * receiving chronic opioid therapy (defined as use of opioids on most days for \>3 months)
  5. * allergy to opioids
  6. * women of childbearing potential who have a positive pregnancy result as part of their standard pre-surgical workup

Contacts and Locations

Study Contact

Jennifer Mull, RN
CONTACT
904-244-7988
Jennifer.Mull@jax.ufl.edu
Ruchir Puri, MD
CONTACT
(904) 244-5502
ruchir.puri@jax.ufl.edu

Principal Investigator

Jana Sacco, MD
PRINCIPAL_INVESTIGATOR
Assistant Professor

Study Locations (Sites)

University of Florida Jacksonville
Jacksonville, Florida, 32209
United States

Collaborators and Investigators

Sponsor: University of Florida

  • Jana Sacco, MD, PRINCIPAL_INVESTIGATOR, Assistant Professor

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-01-29
Study Completion Date2026-07

Study Record Updates

Study Start Date2025-01-29
Study Completion Date2026-07

Terms related to this study

Additional Relevant MeSH Terms

  • Ventral Hernia