CYP2D6 Genotype-guided Management of Opioid Analgesics in Patients Undergoing Elective Ventral Hernia Repairs

Description

Pilot pragmatic trial using an implementation science approach to determine the feasibility of a CYP2D6-guided opioid prescribing for patients undergoing elective VHRs compared to usual care. Assess the efficacy (PROMIS Pain Intensity and Hernia-Related QOL) of a CYP2D6-guided opioid prescribing approach for patients undergoing elective VHRs.

Conditions

Ventral Hernia

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Study Overview

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Study Details

Study overview

Pilot pragmatic trial using an implementation science approach to determine the feasibility of a CYP2D6-guided opioid prescribing for patients undergoing elective VHRs compared to usual care. Assess the efficacy (PROMIS Pain Intensity and Hernia-Related QOL) of a CYP2D6-guided opioid prescribing approach for patients undergoing elective VHRs.

Feasibility and Efficacy of CYP2D6 Genotype-guided Management of Opioid Analgesics in Patients Undergoing Elective Ventral Hernia Repairs: A Pilot Pragmatic Trial

CYP2D6 Genotype-guided Management of Opioid Analgesics in Patients Undergoing Elective Ventral Hernia Repairs

Condition
Ventral Hernia
Intervention / Treatment

-

Contacts and Locations

Jacksonville

University of Florida Jacksonville, Jacksonville, Florida, United States, 32209

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * \> 18 years age undergoing a ventral hernia repair (VHR) ≥1.5 cm in diameter with mesh.
  • * ventral hernia \<1.5 cm
  • * primary ventral hernia repair (VHR) without a mesh
  • * emergency operative procedure
  • * receiving chronic opioid therapy (defined as use of opioids on most days for \>3 months)
  • * allergy to opioids
  • * women of childbearing potential who have a positive pregnancy result as part of their standard pre-surgical workup

Ages Eligible for Study

18 Years to 90 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Florida,

Jana Sacco, MD, PRINCIPAL_INVESTIGATOR, Assistant Professor

Study Record Dates

2026-07