CD34+ Selected Stem Cell for Poor Graft Function or Graft Failure

Eligibility Criteria

• * Recipient of allogeneic transplantation, adult ≥18 years, from any type of donor including matched related, matched unrelated, mismatched related or mismatched unrelated or haploidentical donor transplant.
• * Documented evidence of graft dysfunction or failure (a-c):
• 1. Primary graft Failure: Graft failure is defined as failure to achieve neutrophil engraftment by day +28 or lack of donor chimerism \> 50% by day 45 not due to the underlying malignancy;
• 2. Poor graft function is defined by at least 2 of the following 3 criteria: Hemoglobin \< 8 g/dL, ANC \< 0.5x109/L, and platelets \< 20x109/L. The cytopenia must be unexplained (such as by disease relapse) and unresponsive to hematopoietic growth factors and must last at least 4 weeks;
• 3. Secondary graft failure is defined as poor graft function associated with donor chimerism \< 5% after initial engraftment
• * Transplanted donor availability
• * Negative pregnancy test within seven (7) days of product infusion for women of childbearing potential.
• * Graft failure due to disease relapse or evidence of disease relapse or progression
• * Donor unavailable or unable to collect peripheral HPC by apheresis
• * Responsive to conventional measures (such as, hematopoietic growth factor)
• * Allergic reaction to murine proteins or iron dextran
• * Women of childbearing potential with positive serum HCG