Bacterial Reduction After Supplementary Disinfection Procedures in Infected Root Canals

Description

The purpose of this study is to understand the effect that 3 different types of root canal procedures have on bacteria.

Conditions

Dental Pulp Necroses

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Study Overview

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Study Details

Study overview

The purpose of this study is to understand the effect that 3 different types of root canal procedures have on bacteria.

Bacterial Reduction After Supplementary Disinfection Procedures in Infected Root Canals

Bacterial Reduction After Supplementary Disinfection Procedures in Infected Root Canals

Condition
Dental Pulp Necroses
Intervention / Treatment

-

Contacts and Locations

Iowa City

University of Iowa College of Dentistry and Dental Clinics, Iowa City, Iowa, United States, 52242

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Diagnosis of pulp necrosis with apical periodontitis (AP) confirmed by pulp tests, clinical and radiographic evidence.
  • * Tooth with no response to cold and electric pulp testing (done at screening).
  • * Single canalled premolars with intact pulp chamber walls.
  • * Patient must be 18 years of age or older
  • * Teeth with vital pulp.
  • * Teeth with incomplete root formation (immature with apical periodontitis).
  • * Teeth with extensive crown destruction.
  • * Teeth with previous endodontic treatment or intervention (pulp debridement).
  • * Teeth with acute/ chronic apical abscess.
  • * Teeth with internal or external resorption.
  • * Teeth with non-odontogenic facial pain.
  • * Teeth with periodontal pockets deeper than 4 mm.
  • * Teeth with advanced untreated periodontal disease or recent periodontal surgery.
  • * Teeth with mobility score greater than 2.
  • * Teeth with a fracture or visible crack.
  • * Patients with diabetes or immune compromised conditions.
  • * Patients who received systemic antibiotics within the last 3 months.
  • * Patients taking corticosteroids.
  • * Patients who are pregnant.

Ages Eligible for Study

18 Years to 95 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Abhishek Parolia,

Abhishek Parolia, PhD, MDS, PRINCIPAL_INVESTIGATOR, University of Iowa

Study Record Dates

2026-08