Physiologic Response to Bariatric Surgery and the Impact of Adjunct Semaglutide in Adolescents

Description

The study plans to learn more about what happens to the body after bariatric surgery in people 12 to 24 years old. The study aims to understand why people respond differently to bariatric surgery and how to define success beyond weight loss alone. The study also plans to learn more about whether a medication (semaglutide) can help people 12 to 24 years old who, between 1 and 2 years after bariatric surgery, have not lost as much weight as expected.

Conditions

Obesity, Adolescent Obesity, Body-Weight Trajectory, Weight Loss Trajectory, Bariatric Surgery, Anti-obesity Agents

Study Overview

Study Details

Study overview

The study plans to learn more about what happens to the body after bariatric surgery in people 12 to 24 years old. The study aims to understand why people respond differently to bariatric surgery and how to define success beyond weight loss alone. The study also plans to learn more about whether a medication (semaglutide) can help people 12 to 24 years old who, between 1 and 2 years after bariatric surgery, have not lost as much weight as expected.

Physiologic Response to Bariatric Surgery and the Impact of Adjunct Semaglutide - in Adolescents (the PRESSURE Trial)

Physiologic Response to Bariatric Surgery and the Impact of Adjunct Semaglutide in Adolescents

Condition
Obesity
Intervention / Treatment

-

Contacts and Locations

Aurora

Childrens Hospital Colorado, Aurora, Colorado, United States, 80045

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Signed and dated informed consent form
  • * Willingness to comply with all study procedures and availability for the duration of the study
  • * Male or female biological sex, age 12 through 24 years
  • * In the preoperative pathway for vertical sleeve gastrectomy
  • * Planned Roux-en-Y gastric bypass
  • * Hypothalamic obesity
  • * Type 2 Diabetes
  • * Use of oral glucocorticoids (within 10 days of baseline visit)
  • * Use of metformin (within 3 months of baseline visit)
  • * Use of insulin secretagogues (within 4 half-lives of the medication of baseline visit)
  • * Current use of insulin
  • * Use of anti-obesity medications (within 4 half-lives of the medication of baseline visit)

Ages Eligible for Study

12 Years to 24 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Colorado, Denver,

Jaime Moore, MD MPH, PRINCIPAL_INVESTIGATOR, University of Colorado - Anschutz Medical Campus

Study Record Dates

2027-10