Cannabis, Linked Emotions, and Adolescent Risk Study

Description

The goal of this study is to disentangle relationships between acute cannabis use and withdrawal on proximal depression and suicide risk and recovery in adolescents ages 12-18 years by incorporating time-varying patterns of substance use, mood, and SI. This project aims to guide the development of scalable, individualized, accessible, and affordable interventions aimed to reduce depression and suicide risk among adolescents.

Conditions

Cannabis Use, Depression, Suicidal Ideation, Adolescent Behavior

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Study Overview

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Study Details

Study overview

The goal of this study is to disentangle relationships between acute cannabis use and withdrawal on proximal depression and suicide risk and recovery in adolescents ages 12-18 years by incorporating time-varying patterns of substance use, mood, and SI. This project aims to guide the development of scalable, individualized, accessible, and affordable interventions aimed to reduce depression and suicide risk among adolescents.

Characterizing Proximal Risk for Depressive Symptoms and Suicidal Ideation with Acute Cannabis Use and Withdrawal Among Adolescents Using Ecological Momentary Assessment

Cannabis, Linked Emotions, and Adolescent Risk Study

Condition
Cannabis Use
Intervention / Treatment

-

Contacts and Locations

Boston

Massachusetts General Hopsital, Boston, Massachusetts, United States, 02114

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Ages 12-18;
  • * Current daily or near daily cannabis use (i.e., use ≥ 4 days per week on average; Timeline Followback);
  • * Score ≥ 5 on PHQ-9 (telephone screener) or current depressive episode (Mini International Neuropsychiatric Interview Kid 7.0.2);
  • * Current or recent (past month) SI (passive or active), plan, or attempt (Self-Injurious Thoughts and Behaviors Interview) (Nock et al., 2007);
  • * Access to an internet-capable smartphone (iOS or Android);
  • * Provision of at least 1 collateral contact for risk monitoring;
  • * Provision of informed assent (or consent if 18 years or older) and parent/guardian consent if \<age 18;
  • * Greater than 60% response rate to EMA prompts during the first EMA phase;
  • * No immediate plan to discontinue cannabis use in the next 3 months;
  • * Positive toxicology result for cannabis on baseline urinalysis.
  • * Any factor that impairs ability to comprehend and effectively participate, including acute intoxication at time of consent;
  • * Cannabis use \>4 times/day on average (to maximize likelihood of capturing mood and SI during non-use times);
  • * Inability to speak/write English fluently;
  • * Gross cognitive impairment, for example due to florid psychosis, intellectual disability, developmental delay, or neurodegenerative disease;
  • * Current epilepsy diagnosis;
  • * Individuals who are under the legal protection of the government or state (wards of the state);
  • * Response of "No" to the knowledge check question regarding EMA suicidality response time;
  • * Inability to wear Fitbit device.

Ages Eligible for Study

12 Years to 18 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Massachusetts General Hospital,

Randi M Schuster, PhD, PRINCIPAL_INVESTIGATOR, Massachusetts General Hospital

Study Record Dates

2028-12