Prospective Evaluation Of Delayed Effects Of Pediatric Car T Cell Therapy

Description

This study is being done to learn more about the short-term and long-term side effects of CAR-T cell therapy. Specifically, researchers want to know how often patients get infections, have delays in recovering blood cell counts and/or have damage to the nervous system.

Conditions

B-ALL, Hematologic Malignancy, Solid Tumor

Talk to us

Study Overview

On this page

Study Details

Study overview

This study is being done to learn more about the short-term and long-term side effects of CAR-T cell therapy. Specifically, researchers want to know how often patients get infections, have delays in recovering blood cell counts and/or have damage to the nervous system.

Prospective Evaluation Of Delayed Effects Of Pediatric Car T Cell Therapy (PROSPER)

Prospective Evaluation Of Delayed Effects Of Pediatric Car T Cell Therapy

Condition
B-ALL
Intervention / Treatment

-

Contacts and Locations

Memphis

St. Jude Children's Research Hospital, Memphis, Tennessee, United States, 38105

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Participants must have received an initial systemically-administered CAR T cell infusion within the last 1-3 months (+/- 14 days).
  • * Initial infusion is defined as the first administration of a CAR T cell product the participant has not previously received OR receipt of a CAR T cell product previously received after an interval allogeneic HSCT.
  • * Age ≤ 30 years at CAR T cell infusion.
  • * Active malignancy other than the disease under study.
  • * Planned consolidative HSCT within 3 months post CAR T cell infusion.
  • * Received or planned additional disease directed therapy post CAR T cell infusion.
  • * Inability or unwillingness of research participant or legal guardian/representative to give written informed consent.

Ages Eligible for Study

to 30 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

St. Jude Children's Research Hospital,

Rebecca Epperly, MD, PRINCIPAL_INVESTIGATOR, St. Jude Children's Research Hospital

Study Record Dates

2029-03