Aging, Beta Blockers, and Thermoregulatory Responses

Description

This study will test the hypothesis that the drugs propranolol and metoprolol will result in greater increases in core body temperature during 3 hours of extreme heat exposure in older adults.

Conditions

Heat Stress, Aging

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Study Overview

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Study Details

Study overview

This study will test the hypothesis that the drugs propranolol and metoprolol will result in greater increases in core body temperature during 3 hours of extreme heat exposure in older adults.

Aging, Beta Blockers, and Thermoregulatory Responses

Aging, Beta Blockers, and Thermoregulatory Responses

Condition
Heat Stress
Intervention / Treatment

-

Contacts and Locations

Dallas

IEEM Texas Health Presbyterian Hospital Dallas, Dallas, Texas, United States, 75231

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Healthy and free of any significant medical problems
  • * Normal resting electrocardiogram
  • * 65+ years of age
  • * Controlled cholesterol of less than 200 mg/dl
  • * Controlled blood pressure of less than 140/90 mmHg
  • * Known diseases or other chronic conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, uncontrolled hypertension, and uncontrolled hypercholesterolemia
  • * Serious abnormalities detected on routine screening
  • * Taking prescribed medications or over-the-counter medications that have known influences on either cardiac function or sweating
  • * Current smokers, as well as individuals who regularly smoked within the past 3 years
  • * body mass index ≥31 kg/m2

Ages Eligible for Study

65 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Texas Southwestern Medical Center,

Craig Crandall, PhD, PRINCIPAL_INVESTIGATOR, Univ of Texas Southwestern Med Ctr

Study Record Dates

2026-09-30