RECRUITING

Aging, Beta Blockers, and Thermoregulatory Responses

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study will test the hypothesis that the drugs propranolol and metoprolol will result in greater increases in core body temperature during 3 hours of extreme heat exposure in older adults.

Official Title

Aging, Beta Blockers, and Thermoregulatory Responses

Quick Facts

Study Start:2024-10-04

Study Completion:2026-09-30

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT06582680

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:65 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Healthy and free of any significant medical problems * Normal resting electrocardiogram * 65+ years of age * Controlled cholesterol of less than 200 mg/dl * Controlled blood pressure of less than 140/90 mmHg	* Known diseases or other chronic conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, uncontrolled hypertension, and uncontrolled hypercholesterolemia * Serious abnormalities detected on routine screening * Taking prescribed medications or over-the-counter medications that have known influences on either cardiac function or sweating * Current smokers, as well as individuals who regularly smoked within the past 3 years * body mass index ≥31 kg/m2

Inclusion Criteria

Exclusion Criteria

* Healthy and free of any significant medical problems
* Normal resting electrocardiogram
* 65+ years of age
* Controlled cholesterol of less than 200 mg/dl
* Controlled blood pressure of less than 140/90 mmHg

* Known diseases or other chronic conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, uncontrolled hypertension, and uncontrolled hypercholesterolemia
* Serious abnormalities detected on routine screening
* Taking prescribed medications or over-the-counter medications that have known influences on either cardiac function or sweating
* Current smokers, as well as individuals who regularly smoked within the past 3 years
* body mass index ≥31 kg/m2

Contacts and Locations

Study Contact

Taysom Wallace, MS

CONTACT

214-345-5022

taysomwallace@texashealth.org

Courtney Kirby, RN

CONTACT

214-345-6502

courtneykirby@texashealth.org

Principal Investigator

Craig Crandall, PhD

PRINCIPAL_INVESTIGATOR

Univ of Texas Southwestern Med Ctr

Study Locations (Sites)

IEEM Texas Health Presbyterian Hospital Dallas

Dallas, Texas, 75231

United States

Collaborators and Investigators

Sponsor: University of Texas Southwestern Medical Center

Craig Crandall, PhD, PRINCIPAL_INVESTIGATOR, Univ of Texas Southwestern Med Ctr

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-10-04

Study Completion Date2026-09-30

Study Record Updates

Study Start Date2024-10-04

Study Completion Date2026-09-30

Terms related to this study

Additional Relevant MeSH Terms

Heat Stress
Aging