The REgistry of Very Early Estrogen and AnovuLation

Description

The purpose of this study is to to build a registry of women with early estrogen loss due to Functional Hypothalamic Amenorrhea (FHA) to understand the prevalence, racial and ethnic diversity of this condition.

Conditions

Hypothalamic Amenorrhea, Functional, Hypothalamic Amenorrhea, Functional Hypogonadotropic Hypogonadism

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Study Overview

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Study Details

Study overview

The purpose of this study is to to build a registry of women with early estrogen loss due to Functional Hypothalamic Amenorrhea (FHA) to understand the prevalence, racial and ethnic diversity of this condition.

The REgistry of Very Early Estrogen and AnovuLation

The REgistry of Very Early Estrogen and AnovuLation

Condition
Hypothalamic Amenorrhea, Functional
Intervention / Treatment

-

Contacts and Locations

Jacksonville

Mayo Clinic, Jacksonville, Florida, United States, 32224

Rochester

Mayo Clinic, Rochester, Minnesota, United States, 55905

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 3 or more months of consecutive amenorrhea with a diagnosis of functional hypothalamic amenorrhea or screening hormones consistent with functional hypothalamic amenorrhea including but not limited to:
  • * Estradiol: \< 50pg/mL
  • * LH: \< 10 IU/mL
  • * FSH: \< 10 IU
  • * Testosterone: 2 - 45 ng/dL
  • * Free Testosterone: 0.1 - 6.4 pg/mL
  • * FT4: 0.93 - 1.70 ng/dL
  • * Prolactin: \< 20 ng/mL
  • * AMH: \> 1 ng/mL
  • * Urine or serum human chorionic gonadotropin: Negative
  • * LH:FSH Ratio \<1
  • * No signs of male-like hair growth on the upper lip, chin, chest, abdomen, buttocks, or back
  • * Does not have a diagnosis for secondary amenorrhea, including prolactinoma, PCOS, premature ovarian insufficiency, pituitary surgery, infection, or infarction
  • * Premenopausal status determined by WISE criteria
  • * Able to give informed consent
  • * Able to read English
  • * Parturition/lactating in the last 6-12 months
  • * Lack of consent

Ages Eligible for Study

18 Years to 40 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

Mayo Clinic,

Chrisandra Shufelt, MD, PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

2029-08-01