RECRUITING

Drinking, Acetate, and Stress

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to learn how drinking alcohol affects how people experience stress and how that is affected by the body's chemistry. Specifically, the investigators will be studying relationships of drinking and a stress hormone called cortisol. The investigators believe that results will lead us to find more effective ways to help people stop or reduce drinking when participants are drinking at harmful levels.

Official Title

Role of Acetate in Heavy Drinking

Quick Facts

Study Start:2024-11-06
Study Completion:2030-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06584448

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 50 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Provision of signed and dated informed consent form
  2. * Stated willingness to comply with all study procedures and availability for the duration of the study
  3. * Medically stable male or female, aged 18-55.
  4. * Able to read, write and complete a multitude of self-assessments in English
  5. * Meets DSM-5 criteria for current Alcohol Use Disorder (AUD)
  6. * Participants who have Alcohol Use Disorder and are actively drinking must be willing to receive (at no cost) inpatient treatment for AUD for a period of up to 30 days. Participants who have been treated for an Alcohol Use Disorder and are now sober three months or longer will NOT be required to go inpatient.
  1. * Subjects with any significant current medical conditions (neurological, cardiovascular, endocrine, thyroid, renal, liver), seizures, delirium or hallucinations, or other unstable medical conditions, including HIV.
  2. * Current DSM-5 substance use disorder (other than AUD or tobacco use disorder)
  3. * Any metallic objects implanted in their body which would make imaging unsafe (pacemaker, etc)
  4. * Claustrophobia, or other inability to participate in an MRI
  5. * A positive test result at intake appointment and subsequent appointments on urine drug screens conducted for illicit drugs. (Note: participants will not be paid for study visits if they test positive for an illicit drug and will be immediately excluded from study).
  6. * Women who are pregnant or nursing. Women who have an IUD that would make imaging unsafe.
  7. * Recent taking of medications that may influence study outcomes (e.g., disulfiram, naltrexone, acamprosate, anticonvulsants).
  8. * Subjects likely to exhibit clinically significant alcohol withdrawal during the study.

Contacts and Locations

Study Contact

Graeme Mason, Ph.D.
CONTACT
203-737-1478
graeme.mason@yale.edu
Elizabeth Guidone, B.A.
CONTACT
475-375-6141
elizabeth.guidone@yale.edu

Principal Investigator

Graeme Mason, Ph.D.
PRINCIPAL_INVESTIGATOR
Yale University

Study Locations (Sites)

The Anlyan Center, 300 Cedar St.
New Haven, Connecticut, 06519
United States
Yale University
New Haven, Connecticut, 06520
United States

Collaborators and Investigators

Sponsor: Yale University

  • Graeme Mason, Ph.D., PRINCIPAL_INVESTIGATOR, Yale University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-11-06
Study Completion Date2030-01

Study Record Updates

Study Start Date2024-11-06
Study Completion Date2030-01

Terms related to this study

Keywords Provided by Researchers

  • Brain
  • Stress
  • Imaging
  • Detoxification
  • Recovery
  • Sobriety

Additional Relevant MeSH Terms

  • Alcohol Use Disorder
  • Alcohol Use, Unspecified
  • Heavy Drinker
  • Alcohol Use Disorder, Moderate, in Sustained Remission