RECRUITING

Enhancing Rehabilitation for Veterans With Serious Mental Illness

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study addresses the critical need for innovative therapeutic interventions in Veterans with serious mental illnesses (SMI) receiving care in VA Psychosocial Rehabilitation and Recovery Centers (PRRCs). The vast majority of individuals with SMI suffer from cognitive impairments, leading to chronic functional disability, and impaired outcomes, causing a significant strain on support networks and the VA healthcare system. This study aims to introduce an innovative mental health therapy, Targeted Cognitive Training (TCT), to Veterans struggling with serious mental illnesses (SMI). TCT works to improve basic sensory information processing and, ultimately, clinical, cognitive, and psychosocial functioning. By using EEG biomarkers to identify Veterans with SMI receiving care within VA Psychosocial Rehabilitation and Recovery Centers who are most likely to benefit from this treatment, and by understanding how best to implement this therapy, the investigators hope to enhance care and improve life quality for Veterans with SMI.

Official Title

Enhancing Rehabilitation for Veterans With Serious Mental Illness Via Biomarker-Informed Cognitive Training

Quick Facts

Study Start:2025-02-25
Study Completion:2028-10-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06586164

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 75 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Veterans with SMI (e.g., schizophrenia, schizoaffective disorder, bipolar disorder, PTSD) being treated at PRRCs or co-located rehabilitative services.
  2. * Age 18 and 75 years.
  3. * Fluency in spoken and written English.
  4. * Ability to detect 1000 Hz tones binaurally at a 40-dB sound pressure level.
  5. * Ability to see with an acuity of 20/40 with both eyes tested together (corrected if applicable) by a standard printed Snellen eye chart reading card.
  1. * Estimated premorbid IQ below 70, as estimated via the WRAT-4 Reading subtest.
  2. * Active substance use other than cannabis within the last 30 days as determined by CPRS review, self- report, or positive urine drug screen (obtained as part of the screening process).
  3. * History of significant medical or neurological illness.
  4. * Inability to comprehend or provide informed consent.

Contacts and Locations

Study Contact

Joyce Sprock, BS
CONTACT
(858) 552-8585
joyce.sprock@va.gov
Abigail A Mack
CONTACT
(858) 642-6492
abigail.mack@va.gov

Principal Investigator

Gregory Light, PhD
PRINCIPAL_INVESTIGATOR
VA San Diego Healthcare System, San Diego, CA

Study Locations (Sites)

VA San Diego Healthcare System, San Diego, CA
San Diego, California, 92161-0002
United States

Collaborators and Investigators

Sponsor: VA Office of Research and Development

  • Gregory Light, PhD, PRINCIPAL_INVESTIGATOR, VA San Diego Healthcare System, San Diego, CA

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-02-25
Study Completion Date2028-10-31

Study Record Updates

Study Start Date2025-02-25
Study Completion Date2028-10-31

Terms related to this study

Keywords Provided by Researchers

  • schizophrenia
  • psychosis
  • cognition
  • EEG
  • Serious mental illness
  • PTSD
  • Schizoaffective disorder
  • Bipolar disorder
  • clinical symptoms
  • function

Additional Relevant MeSH Terms

  • Schizophrenia
  • Psychosis
  • Serious Mental Illness
  • PTSD
  • Schizoaffective Disorder
  • Bipolar Disorder