RECRUITING

Neuromodulation of the Cortex and Spinal Cord

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Specific Aim 1: To further quantify the difference in the sensorimotor cortical activity, spinal cord activity, and corticospinal coherence of persons with CP. Overall hypotheses: The sensorimotor cortical activity, spinal cord activity, and corticospinal coherence will be uncharacteristic in persons with CP when compared with neurotypical controls. Furthermore, the extent of the alterations in the sensorimotor cortical activity, spinal cord activity, and corticospinal coherence will be tightly linked with the clinical presentations of persons with CP. Specific Aim 2: To investigate the effect of transcutaneous current stimulation applied over the cortex and/or spinal cord on the sensorimotor cortical activity, spinal cord dynamics, and corticospinal coherence. Overall hypotheses: Compared with the sham controls, those receiving the transcutaneous current stimulation will demonstrate alterations in the strength of the sensorimotor cortical activity, spinal cord activity, and corticospinal coherence. Moreover, the extent of the alterations in the sensorimotor cortical activity, spinal cord activity, and corticospinal coherence will be tightly linked with the clinical presentations of persons with CP.

Official Title

Neuromodulation of the Cortex and Spinal Cord

Quick Facts

Study Start:2024-01-17
Study Completion:2029-08
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06586437

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:11 Years to 45 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:CHILD, ADULT
Inclusion CriteriaExclusion Criteria
  1. * For Cerebral Palsy Participants:
  2. * Gross Motor Function Classification score (GMFCS) levels between I-IV
  3. * For Neurotypical Controls:
  4. * No known atypical neurodevelopment (e.g. autism, Down Syndrome, ADHD, etc.)
  1. * For Cerebral Palsy Participants:
  2. * Pregnancy
  3. * Any condition that, in the opinion of the investigator, is a contraindication to participation
  4. * The presence of any ferrous metal implant, including orthodonture, which may interfere with the MEG data acquisition and/or be an MRI safety concern
  5. * No orthopedic surgery in the last 6 months or metal in their body that would preclude the use of an MRI
  6. * For Neurotypical Controls:
  7. * Any condition that, in the opinion of the investigator, is a contraindication to participation
  8. * The presence of any ferrous metal implant, including orthodonture, which may interfere with the MEG data acquisition and/or be an MRI safety concern
  9. * No orthopedic surgery in the last 6 months or metal in their body that would preclude the use of an MRI

Contacts and Locations

Study Contact

Max J Kurz, PhD
CONTACT
531-355-8916
max.kurz@boystown.org
Jennifer M Kime, MS
CONTACT
531-355-8959

Principal Investigator

Max J Kurz, PhD
PRINCIPAL_INVESTIGATOR
Father Flanagan's Boys' Home

Study Locations (Sites)

Boys Town National Research Hospital
Boys Town, Nebraska, 68010
United States

Collaborators and Investigators

Sponsor: Father Flanagan's Boys' Home

  • Max J Kurz, PhD, PRINCIPAL_INVESTIGATOR, Father Flanagan's Boys' Home

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-01-17
Study Completion Date2029-08

Study Record Updates

Study Start Date2024-01-17
Study Completion Date2029-08

Terms related to this study

Keywords Provided by Researchers

  • Cerebral Palsy
  • Neuromodification
  • Brain
  • Spinal Cord
  • Upper Extremity

Additional Relevant MeSH Terms

  • Cerebral Palsy