Manual Versus AI-Assisted Clinical Trial Screening Using Large-Language Models

Description

A prospective randomized controlled trial comparing manual review and AI screening for patient eligibility determination and enrollments. A structured query will identify potentially eligible patients from the Mass General Brigham Electronic Data Warehouse (EDW), who will then be randomized into either the manual review arm or the AI-assisted review arm.

Conditions

Comparing Manual and AI Patient Screening in Heart Failure

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Study Overview

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Study Details

Study overview

A prospective randomized controlled trial comparing manual review and AI screening for patient eligibility determination and enrollments. A structured query will identify potentially eligible patients from the Mass General Brigham Electronic Data Warehouse (EDW), who will then be randomized into either the manual review arm or the AI-assisted review arm.

Manual Versus AI-Assisted Clinical Trial Screening Using Large-Language Models

Manual Versus AI-Assisted Clinical Trial Screening Using Large-Language Models

Condition
Comparing Manual and AI Patient Screening in Heart Failure
Intervention / Treatment

-

Contacts and Locations

Boston

Brigham and Women's Hospital, Boston, Massachusetts, United States, 02115

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Documented diagnosis of heart failure (e.g., ICD-9 codes 428 ICD-10 codes I50 or Problem list in the electronic health record)
  • * Most recent left ventricular ejection fraction (LVEF) assessed within the past 24 months
  • * Seen Mass General Brigham provider within the last 24 months
  • * LVEF \<50% currently prescribed or intolerant to an evidence-based beta-blocker, ARNI, MRA, and SGLT2i at least 50% goal dose
  • * LVEF\>50% currently prescribed or intolerant to SGLT2i
  • * Systolic blood pressure (SBP) \<90 mmHg at last measure

Ages Eligible for Study

18 Years to 90 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Brigham and Women's Hospital,

Benjamin M Scirica, MD, MSc, STUDY_CHAIR, Brigham and Women's Hospital

Study Record Dates

2024-09-13