Cardiac Radioablation for VT

Description

The goal of this interventional study is to determine the minimum dose necessary for successful cardiac radioablation of refractory ventricular tachycardia (VT) and to study the utility of target volume definition using Delayed Enhancement Cardiac MRI (DE-CMR) .

Conditions

Ventricular Tachycardia, Myocardial Infarction

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Study Overview

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Study Details

Study overview

The goal of this interventional study is to determine the minimum dose necessary for successful cardiac radioablation of refractory ventricular tachycardia (VT) and to study the utility of target volume definition using Delayed Enhancement Cardiac MRI (DE-CMR) .

A Phase I/II Study of Cardiac Radioablation for Refractory Ventricular Tachycardia

Cardiac Radioablation for VT

Condition
Ventricular Tachycardia
Intervention / Treatment

-

Contacts and Locations

Royal Oak

Corewell Health William Beaumont University Hospital, Royal Oak, Michigan, United States, 48073

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Participants must be 18 years or older.
  • * Automatic implanted cardiac defibrillator present.
  • * VT is monomorphic with at least two episodes of VT within an eight week (56 day) period as recorded by an AICD or heart failure related to VT or VT storm.
  • * Ejection fraction ≥20%.
  • * At least one previous cardiac ablation for VT.
  • * VT refractory despite antiarrhythmic medications.
  • * Likely to live for 12 months in the absence of VT.
  • * AICD in a position in the chest RT to be given without direct radiation.
  • * Woman of reproductive age must ensure that she won't become pregnant or breastfeed at the time of RT.
  • * The participant has no contraindications to a Cardiac MRI as per routine Cardiology practice.
  • * Class IV heart failure
  • * Abandoned leads.
  • * Prior radiation therapy to the chest or upper abdomen.
  • * Interstitial lung disease.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

William Beaumont Hospitals,

John Robertson, MD, PRINCIPAL_INVESTIGATOR, Corewell Health William Beaumont University Hospital

Study Record Dates

2026-08