Intrathecal Morphine Versus Intravenous Methadone for Postoperative Analgesia Following Retroperitoneal Lymph Node Dissection.

Description

This randomization study is to compare both intrathecal morphine and intravenous methadone, which are both standard of care, for pain management in patients undergoing retroperitoneal lymph node dissections for primary testicular cancer. Investigators plan to compare their analgesic effectiveness at different postoperative time intervals.

Conditions

Testicular Cancer

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Study Overview

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Study Details

Study overview

This randomization study is to compare both intrathecal morphine and intravenous methadone, which are both standard of care, for pain management in patients undergoing retroperitoneal lymph node dissections for primary testicular cancer. Investigators plan to compare their analgesic effectiveness at different postoperative time intervals.

Randomized Prospective Study Comparing Intrathecal Morphine Vs Intravenous Methadone for Postoperative Analgesia Following Retroperitoneal Lymph Node Dissection (RPLND)

Intrathecal Morphine Versus Intravenous Methadone for Postoperative Analgesia Following Retroperitoneal Lymph Node Dissection.

Condition
Testicular Cancer
Intervention / Treatment

-

Contacts and Locations

Indianapolis

Indiana Univeristy, Indianapolis, Indiana, United States, 46202

Indianapolis

Indiana University Hospital, Indianapolis, Indiana, United States, 46202

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patients undergoing a virgin (chemotherapy has not been used) or post- chemotherapy retroperitoneal lymph node dissection for primary testicular cancer at IU Health AAHC
  • * ASA Class 1, 2, 3
  • * Age 18 to 80 years; Male
  • * BMI less than 50kg/m2
  • * Any contraindication for neuraxial analgesia
  • * Patient on home methadone at any dose
  • * Any physical, mental or medical conditions which, in the opinion of the investigators, may confound quantifying postoperative pain resulting from surgery.
  • * Known true allergy to the study medications (morphine, bupivacaine, acetaminophen, methadone)
  • * Any history of substance abuse in the past 6 months which would include heroin or any other illegal street drugs
  • * End stage liver disease, end stage renal disease
  • * Patient staying intubated after surgery
  • * Patient (home dose) taking more than 30mg PO morphine equivalent (PME) per day
  • * Any additional surgical procedures to the patient with a different surgical incision compared to the standard laparotomy for the RPLND procedure, i.e. thoracic tumor reduction

Ages Eligible for Study

18 Years to 80 Years

Sexes Eligible for Study

MALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

Indiana University,

Gulraj S Chawla, MD, PRINCIPAL_INVESTIGATOR, Indiana University

Study Record Dates

2026-12-31