RECRUITING

Radiotherapy in Combination With Checkpoint Inhibition for Patients With Metastatic Kidney Cancer

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

To evaluate the impact of combining innate immune system activation (with IMSA101) with antigen release (through SAbR/PULSAR) on limited progressing lesions during ongoing adaptive immune system activation (with maintenance Nivo).

Official Title

STING Agonist and Personalized Ultra-fractionated Stereotactic Adaptive Radiotherapy in Combination With Checkpoint Inhibition for Patients With Metastatic Kidney Cancer.

Quick Facts

Study Start:2025-04-01
Study Completion:2028-10
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06601296

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Patients must have metastatic ccRCC.
  2. * Patients must have oligoprogression defined as progression in ≤5 lesions.
  3. * All oligoprogression lesions must be suitable for radiation.
  4. * Patients must have at least one site of disease that can be safely injected with IMSA101.
  5. * Karnofsky Performance Status (KPS) of at least 50%.
  6. * Age ≥ 18 years.
  7. * Patients must have adequate organ and marrow function within 14 days prior to study entry.
  8. * All IMDC risk categories are allowed.
  1. * Patients with progressive ultracentral/central chest lesions will be excluded

Contacts and Locations

Study Contact

SARAH NEUFELD, MANAGER OF CLINICAL RESEARCH, MS, MBA
CONTACT
214 648 1836
Sarah.Hardee@UTSouthwestern.edu
RAQUIBUL HANNAN, MD, PhD.
CONTACT
214 645 7696
Raquibul.Hannan@UTSouthwestern.edu

Principal Investigator

RAQUIBUL HANNAN, MD
PRINCIPAL_INVESTIGATOR
University of Texas Southwestern Medical Center

Study Locations (Sites)

University of Texas Southwestern Medical Center
Dallas, Texas, 75390
United States

Collaborators and Investigators

Sponsor: University of Texas Southwestern Medical Center

  • RAQUIBUL HANNAN, MD, PRINCIPAL_INVESTIGATOR, University of Texas Southwestern Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-04-01
Study Completion Date2028-10

Study Record Updates

Study Start Date2025-04-01
Study Completion Date2028-10

Terms related to this study

Keywords Provided by Researchers

  • renal
  • kidney
  • mrcc
  • metastatic
  • cancer
  • STING
  • PULSAR
  • SABr
  • SPARK
  • nivolumab
  • IMSA 101

Additional Relevant MeSH Terms

  • Metastatic Renal Cell Carcinoma ( mRCC)
  • OligoProgressive Metastatic Disease