The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma

Description

Traumatic injury followed by critical illness provokes pathophysiologic changes in the bone marrow and the gut that contribute to persistent anemia and changes in the microbiome which significantly impact long-term recovery. This project will define the interactions between the stress, chronic inflammation, bone marrow dysfunction, and an altered microbiome which will provide a strong foundation for future clinical interventions to help improve outcomes following severe trauma.

Conditions

Trauma Injury, Trauma, Critical Illness, Microbiome, Chronic Anemia, Acute Blood Loss Anemia

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Study Overview

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Study Details

Study overview

Traumatic injury followed by critical illness provokes pathophysiologic changes in the bone marrow and the gut that contribute to persistent anemia and changes in the microbiome which significantly impact long-term recovery. This project will define the interactions between the stress, chronic inflammation, bone marrow dysfunction, and an altered microbiome which will provide a strong foundation for future clinical interventions to help improve outcomes following severe trauma.

The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma

The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma

Condition
Trauma Injury
Intervention / Treatment

-

Contacts and Locations

Gainesville

UF Academic Research Building, Gainesville, Florida, United States, 32610

Gainesville

UF Health at Shands Hospital, Gainesville, Florida, United States, 32610

Gainesville

UF Laboratory of Inflammation Biology and Surgical Science and Shands Hospital at UF, Gainesville, Florida, United States, 32610

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. All adults (age ≥18).
  • 2. Blunt trauma with an injury severity score \> 15 and a long bone or pelvic fracture requiring open reduction internal fixation or intramedullary fixation
  • 3. Blunt trauma patients with shock, defined by either a systolic BP (SBP) \<90 mm Hg or base deficit (BD) ≥5 meq or lactate ≥ 2 mmol/L or active red blood cell or whole blood transfusion within 6h or arrival
  • 1. Patients not expected to survive greater than 48 hours
  • 2. Prisoners
  • 3. Pregnancy
  • 4. Previous bone marrow transplantation
  • 5. Patients receiving chronic corticosteroids or immunosuppression therapies
  • 6. Patients with End Stage Renal Disease
  • 7. Patients with any pre-existing hematological disease
  • 8. Surgery for repair of injury is greater than seven days after admission to the hospital for trauma
  • 9. Burn injury greater than 20% TBSA
  • 1. All adults (age ≥55).
  • 2. Patient undergoing elective hip repair for non-infectious reasons.
  • 3. Ability to obtain Informed Consent prior to operation.
  • 1. Patients not expected to survive greater than 48 hours
  • 2. Prisoners
  • 3. Pregnancy
  • 4. Previous bone marrow transplantation
  • 5. Patients receiving chronic corticosteroids or immunosuppression therapies
  • 6. Patients with End Stage Renal Disease
  • 7. Patients with any pre-existing hematological disease

Ages Eligible for Study

18 Years to 100 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Florida,

Alicia Mohr, MD, PRINCIPAL_INVESTIGATOR, University of Florida

Study Record Dates

2028-10-01