RECRUITING

Exercise and Monitoring With Post-Hospitalization Muscle Atrophy to Sustain Intrinsic Capacity and Strength

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The aging Veteran population has more frequent inpatient hospitalization than non-Veterans. In addition, older Veterans have an inability to fully recover muscle mass and function after hospital-acquired weakness. The problem of hospital-acquired weakness is greatly increased in at-risk Veteran populations such as those with chronic kidney disease (CKD). The purpose of this collaborative study involving Denver and Baltimore VAMC sites is to improve health through the detection and rehabilitation management of hospital-acquired weakness in those with CKD. The study goals include identifying and monitoring the optimal muscle assessment sites in clinical settings, examining how muscle health impacts length of hospital stay and physical resilience, and determining how home-based and supervised exercise comparatively addresses post-hospitalization physical resilience using performance tests and Veteran feedback.

Official Title

BCCMA: Recovery of Aged Muscle After Disuse Atrophy (REMEDY): Exercise and Monitoring With Post-Hospitalization Muscle Atrophy to Sustain Intrinsic Capacity and Strength (EMPHASIS)

Quick Facts

Study Start:2025-04-11
Study Completion:2029-09-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06607913

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:55 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age \> 55 years
  2. * Diagnosis of stage 3-4 CKD or an eGFR of \<45 mL/min/1.73m2
  1. * Cardiovascular risk: Poorly controlled hypertension (\>160/100)
  2. * Coronary event in past 6 months
  3. * Class III or IV CHF
  4. * symptomatic angina at rest or during exercise
  5. * Syncope in past year, without known resolution of cause
  6. * COPD requiring home oxygen
  7. * Contraindications to resistance training, including history of intracranial or retinal bleeding; Diabetes with active proliferative retinopathy
  8. * History of significant spinal osteoarthritis or spinal stenosis
  9. * Dementia (on medical record review or mini-mental status exam score)

Contacts and Locations

Study Contact

Michael Harris-Love, DSc MPT BS
CONTACT
(720) 857-2802
MICHAEL.HARRIS-LOVE@CUANSCHUTZ.EDU
Katie Boncella, MS
CONTACT
(303) 724-0687
katie.boncella@va.gov

Principal Investigator

Michael Harris-Love, DSc MPT BS
PRINCIPAL_INVESTIGATOR
Rocky Mountain Regional VA Medical Center, Aurora, CO

Study Locations (Sites)

Rocky Mountain Regional VA Medical Center, Aurora, CO
Aurora, Colorado, 80045-7211
United States
Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD
Baltimore, Maryland, 21201
United States

Collaborators and Investigators

Sponsor: VA Office of Research and Development

  • Michael Harris-Love, DSc MPT BS, PRINCIPAL_INVESTIGATOR, Rocky Mountain Regional VA Medical Center, Aurora, CO

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-04-11
Study Completion Date2029-09-30

Study Record Updates

Study Start Date2025-04-11
Study Completion Date2029-09-30

Terms related to this study

Additional Relevant MeSH Terms

  • Chronic Kidney Disease (CKD)