Exercise and Monitoring With Post-Hospitalization Muscle Atrophy to Sustain Intrinsic Capacity and Strength

Description

The aging Veteran population has more frequent inpatient hospitalization than non-Veterans. In addition, older Veterans have an inability to fully recover muscle mass and function after hospital-acquired weakness. The problem of hospital-acquired weakness is greatly increased in at-risk Veteran populations such as those with chronic kidney disease (CKD). The purpose of this collaborative study involving Denver and Baltimore VAMC sites is to improve health through the detection and rehabilitation management of hospital-acquired weakness in those with CKD. The study goals include identifying and monitoring the optimal muscle assessment sites in clinical settings, examining how muscle health impacts length of hospital stay and physical resilience, and determining how home-based and supervised exercise comparatively addresses post-hospitalization physical resilience using performance tests and Veteran feedback.

Conditions

Chronic Kidney Disease (CKD)

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Study Overview

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Study Details

Study overview

The aging Veteran population has more frequent inpatient hospitalization than non-Veterans. In addition, older Veterans have an inability to fully recover muscle mass and function after hospital-acquired weakness. The problem of hospital-acquired weakness is greatly increased in at-risk Veteran populations such as those with chronic kidney disease (CKD). The purpose of this collaborative study involving Denver and Baltimore VAMC sites is to improve health through the detection and rehabilitation management of hospital-acquired weakness in those with CKD. The study goals include identifying and monitoring the optimal muscle assessment sites in clinical settings, examining how muscle health impacts length of hospital stay and physical resilience, and determining how home-based and supervised exercise comparatively addresses post-hospitalization physical resilience using performance tests and Veteran feedback.

BCCMA: Recovery of Aged Muscle After Disuse Atrophy (REMEDY): Exercise and Monitoring With Post-Hospitalization Muscle Atrophy to Sustain Intrinsic Capacity and Strength (EMPHASIS)

Exercise and Monitoring With Post-Hospitalization Muscle Atrophy to Sustain Intrinsic Capacity and Strength

Condition
Chronic Kidney Disease (CKD)
Intervention / Treatment

-

Contacts and Locations

Aurora

Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora, Colorado, United States, 80045-7211

Baltimore

Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD, Baltimore, Maryland, United States, 21201

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age \> 55 years
  • * Diagnosis of stage 3-4 CKD or an eGFR of \<45 mL/min/1.73m2
  • * Cardiovascular risk: Poorly controlled hypertension (\>160/100)
  • * Coronary event in past 6 months
  • * Class III or IV CHF
  • * symptomatic angina at rest or during exercise
  • * Syncope in past year, without known resolution of cause
  • * COPD requiring home oxygen
  • * Contraindications to resistance training, including history of intracranial or retinal bleeding; Diabetes with active proliferative retinopathy
  • * History of significant spinal osteoarthritis or spinal stenosis
  • * Dementia (on medical record review or mini-mental status exam score)

Ages Eligible for Study

55 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

VA Office of Research and Development,

Michael Harris-Love, DSc MPT BS, PRINCIPAL_INVESTIGATOR, Rocky Mountain Regional VA Medical Center, Aurora, CO

Study Record Dates

2029-09-30