RECRUITING

Fasedienol Nasal Spray for the Acute Treatment of Anxiety in Adults With Social Anxiety Disorder (PALISADE-4)

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This U.S. Phase 3 clinical trial is designed to evaluate the efficacy, safety, and tolerability of the acute intranasal (i.n.) administration of Fasedienol Nasal Spray (fasedienol) (3.2 µg) to relieve symptoms of acute anxiety in adult subjects ages 18 through 65 with Social Anxiety Disorder induced by a public speaking challenge (PSC) in a clinical setting. In addition, safety and tolerability of i.n. administration of 3.2 µg of fasedienol, as-needed, up to 6 times per day for up to 12 months, will be assessed in those subjects who complete PALISADE-4 and choose to enter the distinct open-label extension phase of the study.

Official Title

US, Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Clinical Trial of Fasedienol Nasal Spray for the Acute Treatment of Anxiety Induced by a Public Speaking Challenge in Adult Subjects With Social Anxiety Disorder, With an Open-Label Extension (PALISADE-4)

Quick Facts

Study Start:2024-09-16
Study Completion:2026-10
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06615557

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Written informed consent provided prior to conducting any study-specific assessment.
  2. * Male and female adults, 18 through 65 years of age, inclusive.
  3. * Current diagnosis of SAD as defined in the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition, and confirmed by the Mini-International Neuropsychiatric Interview (MINI).
  4. * Clinician-rated Liebowitz Social Anxiety Score (LSAS) total score ≥70 at Screening (Visit 1).
  5. * Clinician-rated Hamilton Depression Rating Scale (HAM-D) (17-items) total score \<16.
  6. * Female subjects of childbearing potential must be able to commit to the consistent and correct use of an effective method of birth control throughout the study
  7. * Subjects must have normal olfactory function
  1. * Any history of bipolar disorder (I or II), schizophrenia, schizoaffective disorder, psychosis, anorexia or bulimia, premenstrual dysphoric disorder, autism spectrum disorder, or obsessive-compulsive disorder.
  2. * Any other current principal or personality disorder (previously known as Axis I or Axis II disorders), except for specific phobias or generalized anxiety disorder, provided that these are not the primary diagnosis.
  3. * Subjects who meet criteria for moderate or severe alcohol use disorder within the 1 year prior to study entry, or any use of illicit substances or tetrahydrocannabinol ("THC") within 2 months prior to study entry.
  4. * In the opinion of the investigator, the subject has a significant risk for suicidal behavior during the course of their participation in the study, or the subject is considered to be an imminent danger to themself or others.
  5. * Clinically significant nasal pathology or history of significant nasal trauma, nasal surgery, total anosmia, or nasal septum perforation that may have damaged the nasal chemosensory epithelium.
  6. * Two or more documented failed adequate treatment trials with a registered medication approved for SAD.
  7. * Currently receiving cognitive-behavioral therapy (CBT), exposure therapy, or acceptance and commitment therapy.
  8. * Subjects taking psychotropic medications within 30 days before Visit 2.
  9. * Use of any over-the-counter product, prescription product, off-label treatment, cannabidiol ("CBD"), or herbal preparation for treatment of the symptoms of anxiety or social anxiety within 30 days before Visit 2.
  10. * Prior participation in a clinical trial involving fasedienol.
  11. * Participation in any other clinical trial within the last 30 days or during the course of the current trial.
  12. * Subjects with a positive urine drug screen.
  13. * Women who have a positive urine pregnancy test.
  14. * Women who are currently breastfeeding are not eligible unless they are willing to stop breastfeeding for the duration of the study.
  15. * Subjects who have tested positive and/or have exhibited symptoms consistent with SARS-CoV-2 infection during the 4 weeks prior to Screening (Visit 1).
  16. * Any clinically significant medical history or findings as determined by the Investigator that could interfere with the objectives of the study or put the participant at risk.

Contacts and Locations

Study Contact

Ester Salman, MPH
CONTACT
650-577-3693
clinicalstudies@vistagen.com

Study Locations (Sites)

Vistagen Clinical Site
Little Rock, Arkansas, 72211
United States
Vistagen Clinical Site
Bellflower, California, 90706
United States
Vistagen Clinical Site
Torrance, California, 90504
United States
Vistagen Clinical Site
Denver, Colorado, 80209
United States
Vistagen Clinical Site
Tampa, Florida, 33629
United States
Vistagen Clinical Site
Decatur, Georgia, 30030
United States
Vistagen Clinical Site
Chicago, Illinois, 60640
United States
Vistagen Clinical Site
Naperville, Illinois, 60563
United States
Vistagen Clinical Site
Las Vegas, Nevada, 89121
United States
Vistagen Clinical Site
Albuquerque, New Mexico, 87109
United States
Vistagen Clinical Site
Austin, Texas, 78759
United States
Vistagen Clinical Site
Houston, Texas, 77055
United States

Collaborators and Investigators

Sponsor: VistaGen Therapeutics, Inc.

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-09-16
Study Completion Date2026-10

Study Record Updates

Study Start Date2024-09-16
Study Completion Date2026-10

Terms related to this study

Keywords Provided by Researchers

  • Fasedienol
  • PH94B
  • social anxiety disorder
  • social anxiety
  • SAD
  • pherine
  • pherine nasal spray
  • acute treatment
  • anxiolytic
  • mental health
  • anxiety
  • performance anxiety
  • anxiety nasal spray
  • anxiety treatment
  • public speaking anxiety
  • social phobia
  • phobic disorders
  • mental disorder
  • speech task

Additional Relevant MeSH Terms

  • Social Anxiety Disorder (SAD)