Mechanisms of Anabolic Resistance in Older Humans

Description

The purpose of this research is to understand how chronic inflammation affects muscle function and responses to exercise in older adults.

Conditions

Aging

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Study Overview

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Study Details

Study overview

The purpose of this research is to understand how chronic inflammation affects muscle function and responses to exercise in older adults.

Mechanisms of Anabolic Resistance in Older Humans

Mechanisms of Anabolic Resistance in Older Humans

Condition
Aging
Intervention / Treatment

-

Contacts and Locations

Rochester

Mayo Clinic, Rochester, Minnesota, United States, 55905

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Diabetes or fasting plasma glucose 126 mg/dL
  • 2. Body mass index (BMI) 30 kg/m2
  • 3. Anemia (female subjects hemoglobin of \<11 g/dl and male subjects hemoglobin \<12 g/dl)
  • 4. Active coronary artery disease or history of unstable macrovascular disease (unstable angina, myocardial infarction, stroke, and revascularization of coronary, peripheral or carotid artery within 3 months of recruitment)
  • 5. Renal failure (serum creatinine \> 1.5mg/dl)
  • 6. Chronic active liver disease (AST\>144IU/L or ALT\>165IU/L)
  • 7. Oral warfarin group medications or history of blood clotting disorders.
  • 8. Smoking
  • 9. Pregnancy or breastfeeding
  • 10. Alcohol consumption greater than 2 glasses/day or other substance abuse
  • 11. Untreated or uncontrolled hypothyroidism
  • 12. Debilitating chronic disease (at the discretion of the investigators)

Ages Eligible for Study

21 Years to 85 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Mayo Clinic,

Ian Lanza, PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

2030-09-16