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AMD and Validation Rod-Meditated Dark Adaptation With Everyday Task Performance

Description

The goal is to conduct a cross-sectional, single timepoint study on older adults with early and intermediate AMD, and with subretinal drusenoid deposits (SDD), and those in normal health, establishing an association between dark adaptation and reading performance under dim illumination, both which depend on rod photoreceptors.

Conditions

Age-Related Macular Degeneration
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Related Conditions:

Age-Related Macular Degeneration

Study Overview

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Study Details

Study overview

The goal is to conduct a cross-sectional, single timepoint study on older adults with early and intermediate AMD, and with subretinal drusenoid deposits (SDD), and those in normal health, establishing an association between dark adaptation and reading performance under dim illumination, both which depend on rod photoreceptors.

AMD and Validating Rod-Meditated Dark Adaptation With Everyday Task Performance

AMD and Validation Rod-Meditated Dark Adaptation With Everyday Task Performance

Condition
Age-Related Macular Degeneration
Intervention / Treatment

-

Contacts and Locations

Durham

Duke Eye Center, Durham, North Carolina, United States, 27710

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Capable and willing to provide consent
  • * Has been diagnosed with early, intermediate dry age-related macular degeneration or geographic atrophy or has a healthy macular for controls
  • * At least 50 years of age
  • * Unable or unwilling to give consent or unable to read consent since the study involves testing which requires reading
  • * Under 50 years of age
  • * Presence of dense cataracts in the study eye (s) that can affect visual function tests
  • * Presence of glaucoma requiring treatment during the study and/or visual field defects
  • * Previous retinal laser or surgical therapy in the study eye(s)
  • * Previous retinal laser or surgical therapy in the study eye(s)
  • * Any other ocular condition requiring long-term therapy or surgery during the study
  • * The participant has photographically significant corneal or media opacities in either eye that would preclude adequate ophthalmic imaging and functional testing
  • * Diagnosis of nystagmus that will interfere with testing
  • * High myopia -8 Diopters or more severe
  • * The participant has, in the opinion of the Investigator, any physical or mental condition that would increase the risk of participation in the study or may interfere with the study procedures, evaluations, and outcome assessments.

Ages Eligible for Study

50 Years to 89 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Duke University,

Eleonora Lad, MD, PhD, PRINCIPAL_INVESTIGATOR, Duke University

Study Record Dates

2027-12-31