RECRUITING

AMD and Validation Rod-Meditated Dark Adaptation With Everyday Task Performance

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Conditions

Age-Related Macular Degeneration

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal is to conduct a cross-sectional, single timepoint study on older adults with early and intermediate AMD, and with subretinal drusenoid deposits (SDD), and those in normal health, establishing an association between dark adaptation and reading performance under dim illumination, both which depend on rod photoreceptors.

Official Title

AMD and Validating Rod-Meditated Dark Adaptation With Everyday Task Performance

Quick Facts

Study Start:2025-08-15
Study Completion:2027-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06619405

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:50 Years to 89 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Capable and willing to provide consent
  2. * Has been diagnosed with early, intermediate dry age-related macular degeneration or geographic atrophy or has a healthy macular for controls
  3. * At least 50 years of age
  1. * Unable or unwilling to give consent or unable to read consent since the study involves testing which requires reading
  2. * Under 50 years of age
  3. * Presence of dense cataracts in the study eye (s) that can affect visual function tests
  4. * Presence of glaucoma requiring treatment during the study and/or visual field defects
  5. * Previous retinal laser or surgical therapy in the study eye(s)
  6. * Previous retinal laser or surgical therapy in the study eye(s)
  7. * Any other ocular condition requiring long-term therapy or surgery during the study
  8. * The participant has photographically significant corneal or media opacities in either eye that would preclude adequate ophthalmic imaging and functional testing
  9. * Diagnosis of nystagmus that will interfere with testing
  10. * High myopia -8 Diopters or more severe
  11. * The participant has, in the opinion of the Investigator, any physical or mental condition that would increase the risk of participation in the study or may interfere with the study procedures, evaluations, and outcome assessments.

Contacts and Locations

Study Contact

Eleonora Lad, MD, PhD
CONTACT
919-684-4359
nora.lad@duke.edu
Alice Ventura
CONTACT
919-681-6585
alice.ventura@duke.edu

Principal Investigator

Eleonora Lad, MD, PhD
PRINCIPAL_INVESTIGATOR
Duke University

Study Locations (Sites)

Duke Eye Center
Durham, North Carolina, 27710
United States

Collaborators and Investigators

Sponsor: Duke University

  • Eleonora Lad, MD, PhD, PRINCIPAL_INVESTIGATOR, Duke University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-08-15
Study Completion Date2027-12-31

Study Record Updates

Study Start Date2025-08-15
Study Completion Date2027-12-31

Terms related to this study

Additional Relevant MeSH Terms

  • Age-Related Macular Degeneration