Dose-Response to Resistance Exercise on Cardiovascular Health

Description

A large body of evidence indicates numerous health benefits of physical activity, including prevention of cardiovascular disease (CVD), the leading cause of death in the US. This evidence has led to US Physical Activity Guidelines that recommend ≥150 min/week of moderate or ≥75 min/week of vigorous aerobic exercise (AE), plus resistance exercise (RE; such as weight lifting) on ≥2 days/week. To date, current research has mostly focused on AE, and we know a great deal about the dose-response relation between AE and health, resulting in clear and practical guidance to the public on the recommended "dose" in min/week. However, currently far less is known about the dose-response for RE: ≥2 days/week are recommended, but with no duration specified. Thus, this project aims to provide clarity on the dose relationship between RE and health. This project will significantly contribute to developing more effective CVD prevention approaches, advancing prescriptive intervention guidelines, by helping to fill the important gaps in knowledge on effective minimum dose, beneficial optimal dose, and safe maximum dose of RE for CVD prevention. Thus, advancing prescriptive intervention guidelines, and provide important insights for future science of physical activity and health.

Conditions

Cardiovascular Risk

Study Overview

Study Details

Study overview

A large body of evidence indicates numerous health benefits of physical activity, including prevention of cardiovascular disease (CVD), the leading cause of death in the US. This evidence has led to US Physical Activity Guidelines that recommend ≥150 min/week of moderate or ≥75 min/week of vigorous aerobic exercise (AE), plus resistance exercise (RE; such as weight lifting) on ≥2 days/week. To date, current research has mostly focused on AE, and we know a great deal about the dose-response relation between AE and health, resulting in clear and practical guidance to the public on the recommended "dose" in min/week. However, currently far less is known about the dose-response for RE: ≥2 days/week are recommended, but with no duration specified. Thus, this project aims to provide clarity on the dose relationship between RE and health. This project will significantly contribute to developing more effective CVD prevention approaches, advancing prescriptive intervention guidelines, by helping to fill the important gaps in knowledge on effective minimum dose, beneficial optimal dose, and safe maximum dose of RE for CVD prevention. Thus, advancing prescriptive intervention guidelines, and provide important insights for future science of physical activity and health.

Dose-Response to Resistance Exercise on Cardiovascular Health

Dose-Response to Resistance Exercise on Cardiovascular Health

Condition
Cardiovascular Risk
Intervention / Treatment

-

Contacts and Locations

Pittsburgh

Physical Activity Research Center (PARC), Pittsburgh, Pennsylvania, United States, 15219

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Non-Smoker
  • * Overweight or Obese: Body Mass Index 25-43 kg/m2
  • * Inactive: not meeting the US resistance and aerobic exercise guidelines over the last 6 months
  • * Unstable coronary heart disease or heart failure
  • * Uncontrolled arrhythmias or severe aortic stenosis
  • * Acute myocarditis, endocarditis, or pericarditis
  • * Cancer, requiring treatment in the past 5 years
  • * Autoimmune diseases, affecting immune system
  • * Plans to be away ≥4 weeks in the next 1 year
  • * Pregnancy/anticipated pregnancy during the study
  • * Other medical condition that is life-threatening or can interfere with or be aggravated by the exercise training
  • * Major risk factors for coronary heart disease
  • * Uncontrolled diabetes or musculoskeletal limitations

Ages Eligible for Study

40 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Pittsburgh,

Duck-chul Lee, PhD, PRINCIPAL_INVESTIGATOR, University of Pittsburgh

Study Record Dates

2027-12