Prevent Cardiac Surgery Associated AKI Trial

Description

Prevent CSA-AKI (Cardiac Surgery Associated Acute Kidney Injury) trial is a double blinded randomized controlled trial, 242 patients undergoing elective cardiopulmonary bypass surgery (CPB)will either receive a placebo or daily 1200 mg of Co enzyme Q10 (CoQ10) and 1000 mg of Glutathione (GSH), the first dose will be given the day before surgery and continues while admitted up to 1 week. Blood and urine samples will be collected. Adverse events related to the study drugs will be collected.

Conditions

Renal Failure, Coronary Artery Disease, Surgery, Surgery-Complications

Study Overview

Study Details

Study overview

Prevent CSA-AKI (Cardiac Surgery Associated Acute Kidney Injury) trial is a double blinded randomized controlled trial, 242 patients undergoing elective cardiopulmonary bypass surgery (CPB)will either receive a placebo or daily 1200 mg of Co enzyme Q10 (CoQ10) and 1000 mg of Glutathione (GSH), the first dose will be given the day before surgery and continues while admitted up to 1 week. Blood and urine samples will be collected. Adverse events related to the study drugs will be collected.

Efficacy of Mitochondrial Directed Therapy in Prevention of Cardiac Surgery Associated AKI Prevent Cardiac Surgery Associated AKI Trial (Prevent CSA-AKI Trial)

Prevent Cardiac Surgery Associated AKI Trial

Condition
Renal Failure
Intervention / Treatment

-

Contacts and Locations

Washington

George Washington University Hospital, Washington, District of Columbia, United States, 20037

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Adult 18-70 years of age
  • * Undergoing elective CPB (Cardiopulmonary Bypass) surgery
  • * Baseline GFR (Glomerular Filtration Rate) ≥45 ml/min
  • * GFR (Glomerular Filtration Rate) \<45 ml/min
  • * Solitary kidney
  • * Status post-kidney transplant
  • * Pregnant women
  • * Allergy to CoQ10
  • * Allergy to Glutathione
  • * Allergy to Cellulose

Ages Eligible for Study

18 Years to 70 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

George Washington University,

Yoosif Abdalla, MD, PRINCIPAL_INVESTIGATOR, George Washington University

Study Record Dates

2028-06-17