Attenuating DEPression with Internet CBT to Slow Cognitive Decline in Older ICU Survivors(ADEPT-ICU)

Description

Depression affects one-third of intensive care unit (ICU) survivors and represents a potentially modifiable target to slow cognitive decline and reduce the risk of Alzheimer's disease and related dementias (ADRD). Our multi-PI team proposes a two-arm RCT called ADEPT-ICU (Attenuating DEPression with Internet CBT to Slow Cognitive Decline in Older ICU Survivors), which will test the efficacy of an internet CBT intervention called Good Days Ahead (GDA) to reduce the burden of subjective cognitive decline (SCD) in older ICU survivors with moderate to severe depressive symptoms after ICU hospitalization.

Conditions

Depression, Cognitive Decline

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Study Overview

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Study Details

Study overview

Depression affects one-third of intensive care unit (ICU) survivors and represents a potentially modifiable target to slow cognitive decline and reduce the risk of Alzheimer's disease and related dementias (ADRD). Our multi-PI team proposes a two-arm RCT called ADEPT-ICU (Attenuating DEPression with Internet CBT to Slow Cognitive Decline in Older ICU Survivors), which will test the efficacy of an internet CBT intervention called Good Days Ahead (GDA) to reduce the burden of subjective cognitive decline (SCD) in older ICU survivors with moderate to severe depressive symptoms after ICU hospitalization.

Attenuating DEPression with Internet CBT to Slow Cognitive Decline in Older ICU Survivors(ADEPT-ICU)

Attenuating DEPression with Internet CBT to Slow Cognitive Decline in Older ICU Survivors(ADEPT-ICU)

Condition
Depression
Intervention / Treatment

-

Contacts and Locations

Indianapolis

Eskenazi Hospital, Indianapolis, Indiana, United States, 46202

Indianapolis

IU Health Methodist Hospital, Indianapolis, Indiana, United States, 46202

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. 50 years of age and older
  • 2. Admitted to the intensive care for greater \> 48 hours
  • 3. Able to understand and provide informed consent
  • 4. Validated depression diagnosis (PHQ-9 \> 10)
  • 5. Willing to participate in cognitive testing
  • 6. Access to a telephone
  • 7. Discharge to home or an independent or assisted living facility
  • 1. Diagnosis of dementia or neurodegenerative disease (e.g. Alzheimer's disease, vascular dementia as per EHR and IQCODE, or Parkinson's disease) or on anti-dementia medications prior to ICU stay
  • 2. Diagnosis of severe mental illness (bipolar disorder, schizophrenia, schizoaffective) as per EHR and screening questions
  • 3. Persistent psychotic symptoms after ICU stay which would interfere with successful completion of intervention
  • 4. Recent or recurrent alcohol or substance use disorder as per HER and Drug Abuse Screening Test
  • 5. Life expectancy less than 1 year (e.g. terminal cancer diagnosis, discharged on hospice)
  • 6. Ischemic or hemorrhagic stroke, traumatic brain injury, or undergoing neurosurgery prior, during or after ICU stay
  • 7. Uncorrected visual or auditory impairment including legal blindness or deaf
  • 8. Status post tracheostomy and not able to communicate
  • 9. Incarcerated or on parole after ICU stay

Ages Eligible for Study

50 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Indiana University,

Babar Khan, MD, MS, PRINCIPAL_INVESTIGATOR, Indiana University

Study Record Dates

2029-10-30