RECRUITING

Prandial Metabolic Phenotyping in Sarcopenic Older Adults Comparing Plant Based and Whey Based Protein

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The researchers overall objective is to determine whether plant and animal protein based proteins affect the anabolic responses across aging populations differently due to specific changes in the essential amino acids (EAA) and non-essential amino acids (NEAA) kinetic responses. The researchers central hypothesis is that a high EAA to NEAA ratio in a protein meal is related to higher anabolic response to the meal. The researchers also hypothesize that the type of NEAA in a protein meal also affects the anabolic capacity of the meal. The researchers rationale is that finding the amino acid composition of a meal that will maximally induce protein anabolism will guide novel nutritional approaches to prevent and treat sarcopenia, thereby reducing both overall economic burden and improving individual patient outcomes.

Official Title

Prandial Metabolic Phenotyping in Sarcopenic Older Adults Comparing Plant Based and Whey Based Protein

Quick Facts

Study Start:2024-02-01
Study Completion:2026-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06628349

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:50 Years to 95 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age 50-95 years old
  2. * Stable body-weight (±5%) for the past 3 months
  3. * Ability to walk, sit down, and stand up (independently or with walking assistance device)
  4. * Willingness to lay supine in bed for up to 6 hours
  5. * Willingness and ability to comply with the protocol
  1. * Established diagnosis and active treatment of chronic disease: Insulin dependent diabetes mellitus, active malignancy, heart disease, kidney disease, liver disease, HIV/AIDS, Asthma (moderate to severe), Hep (A,B, or C)
  2. * History of untreated metabolic disease including hepatic or renal disorder
  3. * Presence of acute illness or metabolically unstable chronic illness
  4. * Hysterectomy
  5. * Active dependence of alcohol or drugs
  6. * Use of short course of oral corticosteroids within 4 weeks preceding study day
  7. * Current use of long-term oral corticosteroids
  8. * Use of protein or amino acids containing nutritional supplements within 5 days of the first study day
  9. * Presence of fever within the last 3 days
  10. * Planned elective surgery requiring 2 or more days of hospitalization during the entire study
  11. * (Possible) pregnancy
  12. * Failure to give informed consent or Investigator's uncertainty about the willingness or ability of the subject
  13. * Already enrolled in another clinical trial
  14. * Any condition according to the PI or nurse that was found during the screening visit, that would interfere with the study or safety of the patient
  15. * Known allergy to any of the components of the feeding (soy, pea, or whey - dairy)
  16. * Established daily diet of vegetarian / vegan composition
  17. * \<23 MoCa score

Contacts and Locations

Study Contact

Marielle Engelen, PhD
CONTACT
979-220-2282
mpkj.engelen@ctral.org
Savanah Knezek, BS
CONTACT
979-442-8468
research@ctral.org

Principal Investigator

Marielle Engelen, PhD
PRINCIPAL_INVESTIGATOR
Texas A&M University
Nicolaas Deutz, MD, PhD
PRINCIPAL_INVESTIGATOR
Texas A&M University

Study Locations (Sites)

Texas A&M University - CTRAL
College Station, Texas, 77845
United States

Collaborators and Investigators

Sponsor: Texas A&M University

  • Marielle Engelen, PhD, PRINCIPAL_INVESTIGATOR, Texas A&M University
  • Nicolaas Deutz, MD, PhD, PRINCIPAL_INVESTIGATOR, Texas A&M University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-02-01
Study Completion Date2026-01

Study Record Updates

Study Start Date2024-02-01
Study Completion Date2026-01

Terms related to this study

Keywords Provided by Researchers

  • Prandial
  • Sarcopenia
  • Plant protein
  • Animal protein

Additional Relevant MeSH Terms

  • Protein Metabolism