Prandial Metabolic Phenotyping in Sarcopenic Older Adults Comparing Plant Based and Whey Based Protein

Description

The researchers overall objective is to determine whether plant and animal protein based proteins affect the anabolic responses across aging populations differently due to specific changes in the essential amino acids (EAA) and non-essential amino acids (NEAA) kinetic responses. The researchers central hypothesis is that a high EAA to NEAA ratio in a protein meal is related to higher anabolic response to the meal. The researchers also hypothesize that the type of NEAA in a protein meal also affects the anabolic capacity of the meal. The researchers rationale is that finding the amino acid composition of a meal that will maximally induce protein anabolism will guide novel nutritional approaches to prevent and treat sarcopenia, thereby reducing both overall economic burden and improving individual patient outcomes.

Conditions

Protein Metabolism

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Study Overview

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Study Details

Study overview

The researchers overall objective is to determine whether plant and animal protein based proteins affect the anabolic responses across aging populations differently due to specific changes in the essential amino acids (EAA) and non-essential amino acids (NEAA) kinetic responses. The researchers central hypothesis is that a high EAA to NEAA ratio in a protein meal is related to higher anabolic response to the meal. The researchers also hypothesize that the type of NEAA in a protein meal also affects the anabolic capacity of the meal. The researchers rationale is that finding the amino acid composition of a meal that will maximally induce protein anabolism will guide novel nutritional approaches to prevent and treat sarcopenia, thereby reducing both overall economic burden and improving individual patient outcomes.

Prandial Metabolic Phenotyping in Sarcopenic Older Adults Comparing Plant Based and Whey Based Protein

Prandial Metabolic Phenotyping in Sarcopenic Older Adults Comparing Plant Based and Whey Based Protein

Condition
Protein Metabolism
Intervention / Treatment

-

Contacts and Locations

College Station

Texas A&M University - CTRAL, College Station, Texas, United States, 77845

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 50-95 years old
  • * Stable body-weight (±5%) for the past 3 months
  • * Ability to walk, sit down, and stand up (independently or with walking assistance device)
  • * Willingness to lay supine in bed for up to 6 hours
  • * Willingness and ability to comply with the protocol
  • * Established diagnosis and active treatment of chronic disease: Insulin dependent diabetes mellitus, active malignancy, heart disease, kidney disease, liver disease, HIV/AIDS, Asthma (moderate to severe), Hep (A,B, or C)
  • * History of untreated metabolic disease including hepatic or renal disorder
  • * Presence of acute illness or metabolically unstable chronic illness
  • * Hysterectomy
  • * Active dependence of alcohol or drugs
  • * Use of short course of oral corticosteroids within 4 weeks preceding study day
  • * Current use of long-term oral corticosteroids
  • * Use of protein or amino acids containing nutritional supplements within 5 days of the first study day
  • * Presence of fever within the last 3 days
  • * Planned elective surgery requiring 2 or more days of hospitalization during the entire study
  • * (Possible) pregnancy
  • * Failure to give informed consent or Investigator's uncertainty about the willingness or ability of the subject
  • * Already enrolled in another clinical trial
  • * Any condition according to the PI or nurse that was found during the screening visit, that would interfere with the study or safety of the patient
  • * Known allergy to any of the components of the feeding (soy, pea, or whey - dairy)
  • * Established daily diet of vegetarian / vegan composition
  • * \<23 MoCa score

Ages Eligible for Study

50 Years to 95 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Texas A&M University,

Marielle Engelen, PhD, PRINCIPAL_INVESTIGATOR, Texas A&M University

Nicolaas Deutz, MD, PhD, PRINCIPAL_INVESTIGATOR, Texas A&M University

Study Record Dates

2026-01