RECRUITING

Optimizing Care for Older Adults Through Thyroid Hormone Deprescribing

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The proposed study focuses on testing a novel adapted evidence-based multilevel intervention, Deprescribing Thyroid Hormone In Older Adults (D-THIO), to support thyroid hormone deprescribing (dose de-escalation and/or discontinuation) in older adults with thyroid hormone overtreatment and/or misuse and reduce patient harm. Findings from this study will lay the groundwork for broad implementation of D-THIO and serve as a model for deprescribing inappropriate medications for other endocrine conditions and conditions with biochemical monitoring.

Official Title

Optimizing Care for Older Adults Through Thyroid Hormone Deprescribing

Quick Facts

Study Start:2024-12-02
Study Completion:2029-04
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06629272

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. age 65 years and older
  2. 2. on thyroid hormone therapy and have a serum Thyroid-stimulating hormone (TSH) \<0.5 mIU/L or are on thyroid hormone therapy for an inappropriate indication
  3. 3. English speaking
  4. 4. without cognitive impairment
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Brittany Gay
CONTACT
734-763-8608
bbartol@umich.edu

Principal Investigator

Maria Papaleontiou
PRINCIPAL_INVESTIGATOR
University of Michigan

Study Locations (Sites)

University of California San Francisco
San Francisco, California, 94143
United States
University of Michigan
Ann Arbor, Michigan, 48109
United States
Henry Ford Health System
Detroit, Michigan, 48202
United States

Collaborators and Investigators

Sponsor: University of Michigan

  • Maria Papaleontiou, PRINCIPAL_INVESTIGATOR, University of Michigan

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-12-02
Study Completion Date2029-04

Study Record Updates

Study Start Date2024-12-02
Study Completion Date2029-04

Terms related to this study

Keywords Provided by Researchers

  • thyroid hormone overtreatment and misuse
  • older adults
  • deprescribing

Additional Relevant MeSH Terms

  • Hypothyroidism