TERMINATED

A Dose-escalation, Dose-finding, and Expansion Study of XL495 in Participants With Locally Advanced or Metastatic Solid Tumors

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this study is to obtain safety, tolerability, PK, and preliminary clinical antitumor activity for XL495 as a single agent and in combination with select cytotoxic agents in participants with locally advanced or metastatic tumors for whom life-prolonging therapies do not exist or available therapies are intolerable/no longer effective.

Official Title

A Dose-escalation, Dose-finding, and Expansion Study of XL495 as a Single Agent and in Combination Therapy in Participants With Locally Advanced or Metastatic Solid Tumors

Quick Facts

Study Start:2024-10-17
Study Completion:2025-05-07
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:TERMINATED

Study ID

NCT06630247

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Locations (Sites)

Exelixis Clinical Site #4
Denver, Colorado, 80218
United States
Exelixis Clinical Site #9
New Haven, Connecticut, 06511
United States
Exelixis Clinical Site #8
Washington, District of Columbia, 20007
United States
Exelixis Clinical Site #10
Jefferson, Louisiana, 70121
United States
Exelixis Clinical Site #7
New York, New York, 10029
United States
Exelixis Clinical SIte #2
Huntersville, North Carolina, 28078
United States
Exelixis Clinical Site #3
Nashville, Tennessee, 37203
United States
Exelixis Clinical Site #5
Nashville, Tennessee, 37203
United States
Exelixis Clinical Site #1
Austin, Texas, 78758
United States
Exelixis Clinical Site #6
Houston, Texas, 77030
United States

Collaborators and Investigators

Sponsor: Exelixis

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-10-17
Study Completion Date2025-05-07

Study Record Updates

Study Start Date2024-10-17
Study Completion Date2025-05-07

Terms related to this study

Keywords Provided by Researchers

  • solid tumor
  • renal tumor
  • metastatic solid tumor
  • urothelial carcinoma

Additional Relevant MeSH Terms

  • Solid Cancers
  • Solid Tumor Cancer
  • Solid Tumor Malignancy
  • Urothelial Cancer (Urinary Bladder, Ureters, or Renal Pelvis Cancer)
  • Metastatic Solid Tumor
  • Locally Advanced Solid Tumor
  • Urothelial Cancer of Renal Pelvis